Sci Rep:女同胞们请注意!压力对健康的影响,类似于垃圾食品

2017-10-21 佚名 生物探索

日常生活中,女性往往承担着更高的焦虑和抑郁概率,这与压力有关。最新一篇由中外团队联合完成的研究表明,压力会改变雌性小鼠肠道菌群的结构和组成,且影响力等同于垃圾食品。

“与垃圾食品一样,压力也同样影响健康,特别是对于女性而言!”

这是《Scientific Reports》期刊最新一篇文章的结论,由杨百翰大学的微生物学和分子生物学教授Laura Bridgewater团队和上海交通大学赵立平教授课题组合作完成。他们发现,压力会改变雌性小鼠肠道菌群的结构,类似于高脂肪饮食对肠道菌的影响。然而对于雄鼠而言,压力对肠道菌群似乎没有影响。

“这一研究新颖之处在于,它将压力与女性肠道微生物的特定变化联系起来。我们有时候认为,压力是一种纯粹的心理反应,但是现在我们知道,它确实会导致明显的生理变化。” Laura Bridgewater教授强调道。

研究方法:饮食、压力和性别

研究团队以8周大的小鼠为模型,将雌鼠、雄鼠分别随机分成两组,其中一组会以高脂肪的食物进行喂养,另一组会摄取标准的鼠粮。喂养16周后,所有小鼠每天都会承受1至两次的轻微压力(例如在冷水中强迫游泳、潮湿的睡觉环境、捕食者的气味),共持续18天。

接下来,主要通过分析压力暴露前后小鼠的粪便样本,确定它们肠道菌群受饮食、压力影响的模式。此外,通过评估小鼠在迷宫中游走的次数、位置评估这些啮齿动物的焦虑程度。

性别差异:压力只改变雌鼠肠道菌群

结果显示,高脂肪饮食背景下,雄性和雌性小鼠都的肠道菌群都发生了显着变化。但是,高脂肪饮食雄鼠焦虑程度比高脂肪雌鼠大,而且前者在应激反应中活动力下降。

对于标准饮食培养的小鼠而言,压力只会导致雌鼠肠道菌群发生变化,就像它们吃了高脂肪食物一样。

这些结果表明,基于肠道菌群的变化差异,压力对于男性和女性会产生不同的影响。虽然这项研究基于小鼠模型完成,但是研究人员认为,它同样适用于人类,特别是女性健康。

原始出处:

Laura C. Bridgewater, Chenhong Zhang, Yanqiu Wu, et al. Gender-based differences in host behavior and gut microbiota composition in response to high fat diet and stress in a mouse model. Scientific Reports 7, Article number: 10776 (2017). doi:10.1038/s41598-017-11069-4.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1668392, encodeId=274f1668392b8, content=<a href='/topic/show?id=652641533df' target=_blank style='color:#2F92EE;'>#垃圾食品#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41533, encryptionId=652641533df, topicName=垃圾食品)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a52126287661, createdName=维他命, createdTime=Thu May 24 03:22:00 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259156, encodeId=264c25915688, content=压力山大.男同志更要保命, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Mon Nov 06 10:37:19 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255265, encodeId=11c32552654c, content=学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/syBKejEucZo9aZXqKib7wdZYRpZOzeEKDyA59Er4fkK2ff1X7w9pfDTWUY75EBCpsNo0iaGqly7sJMtEPI2Pur6Q/0, createdBy=eb672097339, createdName=lucycici, createdTime=Mon Oct 23 06:55:32 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255092, encodeId=9ae72550922c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Oct 22 13:09:56 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255018, encodeId=eb4f255018e2, content=压力胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sun Oct 22 07:45:30 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254870, encodeId=78ad2548e0ad, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Oct 21 12:41:23 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-11-06 sunfeifeiyang

    压力山大.男同志更要保命

    0

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    2017-10-23 lucycici

    学习了!

    0

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    2017-10-22 半夏微凉

    学习了谢谢分享

    0

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    2017-10-22 sunfeifeiyang

    压力胖

    0

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    2017-10-21 Y—xianghai

    学习了新知识

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