Circ-Cardiovasc Inte:经导管主动脉瓣置换术患者的临床结局及预后指标!

2018-03-16 xing.T MedSci原创

由此可见,TAVR是早期肝脏疾病患者重度主动脉瓣狭窄可行的治疗或是肝病根治前的过渡治疗。Child-Pugh B-C级患者、尤其是合并肾损害的患者,具有非常低的存活率,以及TAVR应慎重考虑以避免无效治疗。这些结果可能有助于改善肝病患者的临床决策过程和管理。

慢性肝病是心脏手术患者围手术期发病和死亡的已知危险因素。关于此类患者接受经导管主动脉瓣置换术治疗(TAVR)存在很少的数据。近日,心血管领域权威杂志Circulation: Cardiovascular Interventions上发表了一篇研究文章,研究人员的目的是评估接受TAVR治疗的肝病患者早期和晚期的临床结局,并确定这些患者死亡率的预测因素。

这项多中心研究收集的数据来自于114例慢性肝病患者,这些患者在12个机构接受了TAVR治疗。研究人员采用倾向评分的匹配分析(114对配对)比较了1118例无肝病患者的围手术期和远期结局。

研究人员发现匹配的组间住院死亡率、血管和出血并发症相似。急性肾损伤在肝病患者中较为常见(30.8% vs. 13.5%,P=0.010)。在2年的随访中,虽然组间心血管疾病的死亡率是相似的(9.4% vs. 6.5%;P=0.433),肝病患者非心源性死亡率也较高(26.4% vs. 14.8%;P=0.034)。较低的肾小球滤过率(估计的肾小球滤过率每减少5毫升/分钟的风险比为1.10;95%可信区间为1.03–1.17;P=0.005)和Child Pugh B或C级(风险比为3.11;95%可信区间为1.47–6.56;P=0.003)是慢性肝病患者死亡的预测因子,两个因素同时存在的患者(估计的肾小球滤过率<60 mL/min和Child Pugh B或C级)2年随访的死亡率为83.2%。

由此可见,TAVR是早期肝脏疾病患者重度主动脉瓣狭窄可行的治疗或是肝病根治前的过渡治疗。Child-Pugh B-C级患者、尤其是合并肾损害的患者,具有非常低的存活率,以及TAVR应慎重考虑以避免无效治疗。这些结果可能有助于改善肝病患者的临床决策过程和管理

原始出处:

Gabriela Tirado-Conte,et al. Clinical Outcomes and Prognosis Markers of Patients With Liver Disease Undergoing Transcatheter Aortic Valve Replacement A Propensity Score–Matched Analysis.Circulation: Cardiovascular Interventions.2018. https://doi.org/10.1161/CIRCINTERVENTIONS.117.005727

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    2018-12-10 quxin068
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[GetPortalCommentsPageByObjectIdResponse(id=1938815, encodeId=0e39193881539, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Dec 10 15:55:00 CST 2018, time=2018-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805465, encodeId=a85e180546568, content=<a href='/topic/show?id=e2c0e826827' target=_blank style='color:#2F92EE;'>#经导管主动脉瓣置换术患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78268, encryptionId=e2c0e826827, topicName=经导管主动脉瓣置换术患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec37461, createdName=szhvet, createdTime=Fri Jan 04 03:55:00 CST 2019, time=2019-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843158, encodeId=17921843158ec, content=<a href='/topic/show?id=3d052296e4e' target=_blank style='color:#2F92EE;'>#临床结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22967, encryptionId=3d052296e4e, topicName=临床结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Thu Mar 29 19:55:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742475, encodeId=b5081e42475a9, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Sun Mar 18 10:55:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536528, encodeId=056415365281c, content=<a href='/topic/show?id=a894e826546' target=_blank style='color:#2F92EE;'>#经导管主动脉瓣置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78265, encryptionId=a894e826546, topicName=经导管主动脉瓣置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b38112697961, createdName=yytms, createdTime=Sun Mar 18 10:55:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510124, encodeId=2bb71510124ee, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Sun Mar 18 10:55:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415289, encodeId=f9e51415289d0, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Sun Mar 18 10:55:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374175, encodeId=7c5f13e417569, content=<a href='/topic/show?id=8de610018644' target=_blank style='color:#2F92EE;'>#预后指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100186, encryptionId=8de610018644, topicName=预后指标)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca3c375, createdName=jwf_2001, createdTime=Sun Mar 18 10:55:00 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
    2019-01-12 yxch48
  5. [GetPortalCommentsPageByObjectIdResponse(id=1938815, encodeId=0e39193881539, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Dec 10 15:55:00 CST 2018, time=2018-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805465, encodeId=a85e180546568, content=<a href='/topic/show?id=e2c0e826827' target=_blank style='color:#2F92EE;'>#经导管主动脉瓣置换术患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78268, encryptionId=e2c0e826827, topicName=经导管主动脉瓣置换术患者)], attachment=null, authenticateStatus=null, createdAvatar=, 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18 10:55:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374175, encodeId=7c5f13e417569, content=<a href='/topic/show?id=8de610018644' target=_blank style='color:#2F92EE;'>#预后指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100186, encryptionId=8de610018644, topicName=预后指标)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca3c375, createdName=jwf_2001, createdTime=Sun Mar 18 10:55:00 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
  6. 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  7. 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  8. 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    2018-03-18 lsj631
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