肿瘤科

订阅

MedSci主页 / 所有栏目 / 肿瘤科

Blood：在慢性淋巴细胞白血病中，Wnt5a诱导ROR1招募DOCK2激活Rac1/2，从而增强CLL细胞增殖

2018-04-21 MedSci MedSci原创

慢性淋巴细胞白血病Wnt5aDOCK2ROR1
关注

中心点：Wnt5a可通过诱导ROR1与DOCK2互作增强Rac1/2的激活。ROR1-DOCK2互作有助于Wnt5a增强的CLL细胞增殖。摘要：酪氨酸激酶样孤儿受体1（ROR1）是表达在慢性淋巴细胞白血病（CLL）细胞上的一种癌胚蛋白，可作为Wnt5a的受体，促进白血病细胞迁移、增殖和存活。研究人员发现Wnt5a可诱导ROR1与DOCK2形成复合物，从而诱导激活Rac1/2；这一效应可可被cirm

中心点：

Wnt5a可通过诱导ROR1与DOCK2互作增强Rac1/2的激活。

ROR1-DOCK2互作有助于Wnt5a增强的CLL细胞增殖。

摘要：

酪氨酸激酶样孤儿受体1（ROR1）是表达在慢性淋巴细胞白血病（CLL）细胞上的一种癌胚蛋白，可作为Wnt5a的受体，促进白血病细胞迁移、增殖和存活。研究人员发现Wnt5a可诱导ROR1与DOCK2形成复合物，从而诱导激活Rac1/2；这一效应可可被cirmtuzumab（人源性抗ROR1 mAb的单克隆抗体）所阻断。

沉默DOCK2可显着破坏Wnt5a诱导激活Rac1/2或增强CLL样细胞增殖的能力。研究人员设计合成ROR1的截断形式发现，在CLL细胞系MEC1中，Wnt5a激活ROR1与DOCK2形成复合物以及激活Rachel/2均需要ROR1胞质内富集脯氨酸的结构域（PRD）。

研究人员在ROR1-PRD上可能与DOCK2的Src-homology3（SH3） 结构域结合的位点将一个脯氨酸（P）变为丙氨酸（A）。与野生型ROR1相反，或其他ROR1 P->A突变，ROR1[P808A]不能再对Wnt5a产生反应招募DOCK2。而且，与转染野生型ROR1或在784、826或841位点发生P->A替换的ROR1的MEC1细胞不同，转染表达ROR1[P808A]的MEC1细胞，对比不表达ROR1的MEC1细胞，无生长优势。

本研究表明DOCK2的募集可能对Wnt5a增强CLL增殖的能力至关重要，其可能是有助于推进高表达ROR1的CLL患者的病程进展。

原始出处：

Md Kamrul Hasan， et al.Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia. Blood  2018  ：blood-2017-12-819383；  doi： https：//doi.org/10.1182/blood-2017-12-819383

本文系梅斯医学（MedSci）原创编译，转载需授权！

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1997893, encodeId=f92b199e8934e, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Jul 04 22:30:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2015860, encodeId=63cb20158603e, content=<a href='/topic/show?id=b45461e840' target=_blank style='color:#2F92EE;'>#DOCK2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6178, encryptionId=b45461e840, topicName=DOCK2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e72268, createdName=zhixianchen, createdTime=Mon Sep 17 01:30:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309019, encodeId=bb2f309019e3, content=学习了.获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Wed Apr 25 06:05:25 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302159, encodeId=083d1302159b4, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540920, encodeId=2caa1540920a3, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548529, encodeId=38821548529d7, content=<a href='/topic/show?id=6a4756229d9' target=_blank style='color:#2F92EE;'>#招募#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56229, encryptionId=6a4756229d9, topicName=招募)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=038c14086626, createdName=ms1260584454294838, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598597, encodeId=e1c4159859ef9, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308178, encodeId=add23081e8b0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Sun Apr 22 09:01:47 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-07-04 sunyl07

    #淋巴细胞白血病#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1997893, encodeId=f92b199e8934e, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Jul 04 22:30:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2015860, encodeId=63cb20158603e, content=<a href='/topic/show?id=b45461e840' target=_blank style='color:#2F92EE;'>#DOCK2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6178, encryptionId=b45461e840, topicName=DOCK2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e72268, createdName=zhixianchen, createdTime=Mon Sep 17 01:30:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309019, encodeId=bb2f309019e3, content=学习了.获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Wed Apr 25 06:05:25 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302159, encodeId=083d1302159b4, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540920, encodeId=2caa1540920a3, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548529, encodeId=38821548529d7, content=<a href='/topic/show?id=6a4756229d9' target=_blank style='color:#2F92EE;'>#招募#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56229, encryptionId=6a4756229d9, topicName=招募)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=038c14086626, createdName=ms1260584454294838, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598597, encodeId=e1c4159859ef9, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308178, encodeId=add23081e8b0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Sun Apr 22 09:01:47 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-09-17 zhixianchen

    #DOCK2#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1997893, encodeId=f92b199e8934e, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Jul 04 22:30:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2015860, encodeId=63cb20158603e, content=<a href='/topic/show?id=b45461e840' target=_blank style='color:#2F92EE;'>#DOCK2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6178, encryptionId=b45461e840, topicName=DOCK2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e72268, createdName=zhixianchen, createdTime=Mon Sep 17 01:30:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309019, encodeId=bb2f309019e3, content=学习了.获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Wed Apr 25 06:05:25 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302159, encodeId=083d1302159b4, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540920, encodeId=2caa1540920a3, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548529, encodeId=38821548529d7, content=<a href='/topic/show?id=6a4756229d9' target=_blank style='color:#2F92EE;'>#招募#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56229, encryptionId=6a4756229d9, topicName=招募)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=038c14086626, createdName=ms1260584454294838, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598597, encodeId=e1c4159859ef9, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308178, encodeId=add23081e8b0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Sun Apr 22 09:01:47 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-25 Ramsey

    学习了.获益匪浅!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1997893, encodeId=f92b199e8934e, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Jul 04 22:30:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2015860, encodeId=63cb20158603e, content=<a href='/topic/show?id=b45461e840' target=_blank style='color:#2F92EE;'>#DOCK2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6178, encryptionId=b45461e840, topicName=DOCK2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e72268, createdName=zhixianchen, createdTime=Mon Sep 17 01:30:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309019, encodeId=bb2f309019e3, content=学习了.获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Wed Apr 25 06:05:25 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302159, encodeId=083d1302159b4, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540920, encodeId=2caa1540920a3, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548529, encodeId=38821548529d7, content=<a href='/topic/show?id=6a4756229d9' target=_blank style='color:#2F92EE;'>#招募#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56229, encryptionId=6a4756229d9, topicName=招募)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=038c14086626, createdName=ms1260584454294838, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598597, encodeId=e1c4159859ef9, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308178, encodeId=add23081e8b0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Sun Apr 22 09:01:47 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-23 wetgdt

    #淋巴细胞#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1997893, encodeId=f92b199e8934e, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Jul 04 22:30:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2015860, encodeId=63cb20158603e, content=<a href='/topic/show?id=b45461e840' target=_blank style='color:#2F92EE;'>#DOCK2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6178, encryptionId=b45461e840, topicName=DOCK2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e72268, createdName=zhixianchen, createdTime=Mon Sep 17 01:30:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309019, encodeId=bb2f309019e3, content=学习了.获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Wed Apr 25 06:05:25 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302159, encodeId=083d1302159b4, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540920, encodeId=2caa1540920a3, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548529, encodeId=38821548529d7, content=<a href='/topic/show?id=6a4756229d9' target=_blank style='color:#2F92EE;'>#招募#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56229, encryptionId=6a4756229d9, topicName=招募)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=038c14086626, createdName=ms1260584454294838, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598597, encodeId=e1c4159859ef9, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308178, encodeId=add23081e8b0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Sun Apr 22 09:01:47 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-23 晓辰

    #细胞增殖#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1997893, encodeId=f92b199e8934e, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Jul 04 22:30:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2015860, encodeId=63cb20158603e, content=<a href='/topic/show?id=b45461e840' target=_blank style='color:#2F92EE;'>#DOCK2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6178, encryptionId=b45461e840, topicName=DOCK2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e72268, createdName=zhixianchen, createdTime=Mon Sep 17 01:30:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309019, encodeId=bb2f309019e3, content=学习了.获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Wed Apr 25 06:05:25 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302159, encodeId=083d1302159b4, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540920, encodeId=2caa1540920a3, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548529, encodeId=38821548529d7, content=<a href='/topic/show?id=6a4756229d9' target=_blank style='color:#2F92EE;'>#招募#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56229, encryptionId=6a4756229d9, topicName=招募)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=038c14086626, createdName=ms1260584454294838, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598597, encodeId=e1c4159859ef9, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308178, encodeId=add23081e8b0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Sun Apr 22 09:01:47 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-23 ms1260584454294838

    #招募#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1997893, encodeId=f92b199e8934e, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Jul 04 22:30:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2015860, encodeId=63cb20158603e, content=<a href='/topic/show?id=b45461e840' target=_blank style='color:#2F92EE;'>#DOCK2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6178, encryptionId=b45461e840, topicName=DOCK2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e72268, createdName=zhixianchen, createdTime=Mon Sep 17 01:30:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309019, encodeId=bb2f309019e3, content=学习了.获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Wed Apr 25 06:05:25 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302159, encodeId=083d1302159b4, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540920, encodeId=2caa1540920a3, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548529, encodeId=38821548529d7, content=<a href='/topic/show?id=6a4756229d9' target=_blank style='color:#2F92EE;'>#招募#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56229, encryptionId=6a4756229d9, topicName=招募)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=038c14086626, createdName=ms1260584454294838, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598597, encodeId=e1c4159859ef9, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308178, encodeId=add23081e8b0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Sun Apr 22 09:01:47 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-23 zhwj

    #WNT#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1997893, encodeId=f92b199e8934e, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Jul 04 22:30:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2015860, encodeId=63cb20158603e, content=<a href='/topic/show?id=b45461e840' target=_blank style='color:#2F92EE;'>#DOCK2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6178, encryptionId=b45461e840, topicName=DOCK2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e72268, createdName=zhixianchen, createdTime=Mon Sep 17 01:30:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309019, encodeId=bb2f309019e3, content=学习了.获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Wed Apr 25 06:05:25 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302159, encodeId=083d1302159b4, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540920, encodeId=2caa1540920a3, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548529, encodeId=38821548529d7, content=<a href='/topic/show?id=6a4756229d9' target=_blank style='color:#2F92EE;'>#招募#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56229, encryptionId=6a4756229d9, topicName=招募)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=038c14086626, createdName=ms1260584454294838, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598597, encodeId=e1c4159859ef9, content=<a href='/topic/show?id=c4da18e2588' target=_blank style='color:#2F92EE;'>#WNT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18725, encryptionId=c4da18e2588, topicName=WNT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb3518632538, createdName=zhwj, createdTime=Mon Apr 23 05:30:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308178, encodeId=add23081e8b0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Sun Apr 22 09:01:47 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-22 Ramsey

    学习了

    0

相关资讯

重磅：伊布替尼的出血副作用得到了解决！

重磅：伊布替尼的出血副作用得到了解决！ 近日，研究人员通过光传导聚集测定评估了慢性淋巴细胞白血病患者血小板聚集情况，发现伊布替尼的使用不影响Ristocetin诱导的血小板聚集。

NCCN临床实践指南：慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（2018.V5）

2018年3月，美国国家综合癌症网络(NCCN)发布了慢性淋巴细胞白血病/小淋巴细胞淋巴瘤指南2018年第5版，指南主要内容涉及： 指南更新摘要 慢性淋巴细胞白血病/小淋巴细胞淋巴瘤的诊断、检查、分期 虚弱患者的严重合并症 没有17p缺失或Tp53突变的慢性淋巴细胞白血病／小淋巴细胞淋巴瘤 17p缺失或Tp53突变的慢性淋巴细胞白血病／小淋巴细胞淋巴瘤 慢性淋巴细胞白血病／小淋巴细胞淋巴瘤的预后信

NEJM： Venetoclax-Rituximab用于复发难治性慢性淋巴细胞白血病

研究认为，对于复发难治性慢性淋巴细胞白血病患者，Venetoclax联合利妥昔单抗的疾病控制效果显著优于现行的免疫化疗方法

Lancet haemat：Voxtalisib（XL765）用于滤泡性淋巴瘤患者可获得良好的治疗效果

复发性/难治性淋巴瘤或慢性淋巴系白血病患者预后差。靶向多种类型的PI3K（如mTOR）的治疗方式或可增强抗肿瘤活性。现有研究人员对voxtalisib（XL765或SAR245409）——一种fan-PI3K/mTOR抑制剂——用于复发性/难治性淋巴瘤或慢性淋巴细胞白血病/小淋巴细胞白血病患者的疗效和安全性进行评估。研究人员在多个国家的30个肿瘤诊所进行一非随机的开放性临床2期试验，招募年满18岁

初治和复发/难治性慢性淋巴细胞白血病使用伊布替尼单药治疗的5年经验

初治和复发/难治性慢性淋巴细胞白血病使用伊布替尼单药治疗的5年经验 研究人员先前已经报道了未接受过治疗（TN）的老年患者（≥65岁）和慢性淋巴细胞白血病/小淋巴细胞性淋巴瘤的复发/难治性（R/R）患者的3年随访中伊布替尼的持久应答和可管理的安全性（CLL / SLL）数据。在此，研究人员进一步报道了长期有效性和安全性，对TN患者（N=31）和R/R（N=101）患者进行5年随访。随着5年随访的进

NCCN临床实践指南：慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（2018.V4）

2018年3月，美国国家综合癌症网络(NCCN)发布了慢性淋巴细胞白血病/小淋巴细胞淋巴瘤指南2018年第4版，指南主要内容涉及： 指南更新摘要 慢性淋巴细胞白血病/小淋巴细胞淋巴瘤的诊断、检查、分期 虚弱患者的严重合并症 没有17p缺失或Tp53突变的慢性淋巴细胞白血病／小淋巴细胞淋巴瘤 17p缺失或Tp53突变的慢性淋巴细胞白血病／小淋巴细胞淋巴瘤 慢性淋巴细胞白血病／小淋巴细胞淋巴瘤的预后信