Acta Physiologica: 消炎药能抑制肌肉生长

2017-08-29 MedSci MedSci原创

根据卡罗林斯卡学院的一项新的研究,进行重量训练的年轻、健康人群若长期使用非处方抗炎药,会抑制肌肉的增长。并报道了布洛芬对骨骼肌的影响,研究发表在Acta Physiologica上。除扑热息痛之外,大多数解热镇痛的非处方药都是NSAID(非甾体类抗炎药)。这些药物是世界上被广泛使用的药物,它们都能抑制所谓的COX酶。在本研究中,18至35岁的健康男性和女性被随机分为两组,一组每天服用较高剂量的NS


根据卡罗林斯卡学院的一项新的研究,进行重量训练的年轻、健康人群若长期使用非处方抗炎药,会抑制肌肉的增长。并报道了布洛芬对骨骼肌的影响,研究发表在Acta Physiologica上。
除扑热息痛之外,大多数解热镇痛的非处方药都是NSAID(非甾体类抗炎药)。这些药物是世界上被广泛使用的药物,它们都能抑制所谓的COX酶。

在本研究中,18至35岁的健康男性和女性被随机分为两组,一组每天服用较高剂量的NSAID(1,200毫克布洛芬,正常24小时剂量),另一组服用相对低剂量(75mg阿司匹林),为时8周。在同一时期,参与者还每周进行两到三次大腿肌肉的有监督的重量训练。然后,研究人员测量了肌肉中的某些变量,如肌肉生长,肌肉力量和抗炎标志物。

结果发现,八周后,低剂量阿司匹林组的肌肉体积增加,是大剂量布洛芬组的两倍。

"研究结果非常有趣,因为消炎药的使用在全球范围内都很普遍,尤其是在精英运动员和进行休闲活动的人群中," 卡罗林斯卡学院医学研究院的首席研究员汤米·伦德伯格(Tommy Lundberg)说。"我们选择研究布洛芬的作用,因为它是市场上研究最充分的抗炎药,但我们相信,高剂量的所有非甾体抗炎药都有类似的效果。"

高剂量的消炎药也削弱了肌肉的力量,但并没有达到如此显着的程度。肌肉活检分析显示,在布洛芬组的肌肉中,炎症的经典标志物被抑制。

伦德伯格博士说:"这表明肌肉的炎症过程与重量训练相结合有利于新肌肉群的长期发展,至少在年轻人中是如此。" "我们的研究结果表明,那些进行重量训练来增加肌肉质量的年轻人应该避免服用高剂量的抗炎药物。"

研究结果在一定程度上与老年人群的研究相矛盾,这些研究表明,消炎药可以预防与年龄相关的肌肉质量损失。因此,研究人员认为,在老年人和年轻人之间,调节肌肉质量的机制是不同的。


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    2018-03-02 仁医06
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    2017-08-31 canlab
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    2017-08-30 thlabcde

    好东西学习了!

    0

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    2017-08-30 戒馋,懒,贪

    超厉害的说.有点意思

    0

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