Chest:COPD患者嗜酸性粒细胞水平与再住院率的关系

2017-06-09 许奕晗 MedSci原创

COPD患者中有一部人群会在痰液或是血液中检测出嗜酸性粒细胞性炎症。之前关于血液中嗜酸性粒细胞水平升高与不良再住院率之间关系的研究结果存在很多争议。

COPD患者中有一部人群会在痰液或是血液中检测出嗜酸性粒细胞性炎症。之前关于血液中嗜酸性粒细胞水平升高与不良再住院率之间关系的研究结果存在很多争议。


近期,加拿大舍布鲁尔(Sherbrooke)大学研究中心完成了一项观察性的研究,探讨了COPD急性恶化导致再住院与血液中嗜酸性粒细胞之间的联系。研究人员回顾性收集了167例严重COPD病患的住院数据,其中包括数次住院累及时间超过一年的患者,接着将入院时嗜酸性粒细胞计数≥200cells/μl和(或)≥2%总白细胞数量归为嗜酸性粒细胞组,其余为对照组,观察患者12个月内COPD相关的再入院次数以及住院时间,然后通过logistic回归模型,负二项和Cox回归模型进行数据分析。结果发现,嗜酸性粒细胞增多与一年内再入院之间存在正相关关系(OR=3.59 [95%CI, 1.10-4.92], p=0.0013),住院时间与嗜酸性粒细胞数量之间则不存在统计学意义。

本篇报道得出一个结论:血液嗜酸性粒细胞的水平可以作为判断COPD严重程度的生物标志物,并可以用来预测患者再入院的可能性。

原始出处:

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    2018-04-20 Smile2680
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    2017-06-17 xuyihan

    copd患者的情况千变万化要仔细检查

    0

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    2017-06-17 xuyihan

    怎都没人了

    0

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    2017-06-11 gous

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