JAMA:儿童营养缺铁性贫血的治疗

2017-06-14 MedSci medicalxpress

在JAMA发表的一项研究中,休斯敦贝勒医学院的Jacquelyn M. Powers博士和他的同事比较了硫酸亚铁和铁多糖复合物两种药物在婴幼儿营养缺铁性贫血治疗中的作用。硫酸亚铁是最常用的口服铁剂,但铁多糖复合物具有更好的耐受性。全世界数百万人患缺铁性贫血(IDA)症,其中美国1到2岁的儿童患病率高达3%,该病与婴幼儿的神经发育受损有关。在研究群体中,最常见的IDA的原因是由于过量的牛奶摄入,长时

在JAMA发表的一项研究中,休斯敦贝勒医学院的Jacquelyn M. Powers博士和他的同事比较了硫酸亚铁和铁多糖复合物两种药物在婴幼儿营养缺铁性贫血治疗中的作用。

硫酸亚铁是最常用的口服铁剂,但铁多糖复合物具有更好的耐受性。全世界数百万人患缺铁性贫血(IDA)症,其中美国1到2岁的儿童患病率高达3%,该病与婴幼儿的神经发育受损有关。

在研究群体中,最常见的IDA的原因是由于过量的牛奶摄入,长时间的母乳喂养而没有适当的补铁,或者两者兼而有之。

在这项研究中,研究人员将80名婴幼儿随机分配,年龄在9个月到4岁之间,连续12周每天补充3mg/kg的硫酸亚铁或铁多糖复合物;其中59人完成了该试验(28人即70%的受试者为硫酸亚铁服用者。31人(78%)的接受铁多糖复合物。作者发现,12周后,与铁多糖复合物组相比,硫酸亚铁组的血红蛋白浓度增加得更多。在硫酸亚铁组中,IDA完全治愈的婴幼儿比例更高(29%比 6%)。

作者写道:"营养缺铁性贫血的儿童,建议服用低剂量硫酸亚铁,每日一次。"

这项研究的局限性在于它是在一家三级护理儿童医院进行的。

原文出处:Jacquelyn M. Powers. et,al.Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency AnemiaA Randomized Clinical Trial.JAMA. 2017;317(22):2297-2304.

此文系梅斯医学(MedSci)原创整理编译,转载需授权!


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    2017-12-13 zutt
  2. 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    2017-06-18 139****5926

    好文章学习了

    0

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  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Jun 15 11:10:15 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211007, encodeId=51f321100eef, content=学习了。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Thu Jun 15 08:11:05 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210954, encodeId=d65621095440, content=学习了,日常日常息息相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, 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objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4aQ9o3mwLf8g71RU8wyNNNCPdJSZhENIsqBjKUicL8BJXLqL2NMl0MlhjIRlv5Bpg0M3UZKuDlwhwLH8B3v2yNy/0, createdBy=11a82069421, createdName=136****3321, createdTime=Thu Jun 15 06:33:40 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210863, encodeId=ac4c210863a2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Thu Jun 15 06:02:42 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210818, encodeId=f20c210818b5, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Wed Jun 14 22:58:08 CST 2017, time=2017-06-14, status=1, ipAttribution=)]
    2017-06-15 139****5926

    好文章学习了

    0

  5. 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objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4aQ9o3mwLf8g71RU8wyNNNCPdJSZhENIsqBjKUicL8BJXLqL2NMl0MlhjIRlv5Bpg0M3UZKuDlwhwLH8B3v2yNy/0, createdBy=11a82069421, createdName=136****3321, createdTime=Thu Jun 15 06:33:40 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210863, encodeId=ac4c210863a2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Thu Jun 15 06:02:42 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210818, encodeId=f20c210818b5, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Wed Jun 14 22:58:08 CST 2017, time=2017-06-14, status=1, ipAttribution=)]
    2017-06-15 1dd7a091m35(暂无匿称)

    学习了。。。。。。。

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4aQ9o3mwLf8g71RU8wyNNNCPdJSZhENIsqBjKUicL8BJXLqL2NMl0MlhjIRlv5Bpg0M3UZKuDlwhwLH8B3v2yNy/0, createdBy=11a82069421, createdName=136****3321, createdTime=Thu Jun 15 06:33:40 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210863, encodeId=ac4c210863a2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Thu Jun 15 06:02:42 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210818, encodeId=f20c210818b5, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Wed Jun 14 22:58:08 CST 2017, time=2017-06-14, status=1, ipAttribution=)]
    2017-06-15 惠映实验室

    学习了,日常日常息息相关

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Jun 15 07:06:43 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210951, encodeId=d8092109514a, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jun 15 07:04:27 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210900, encodeId=e264210900c5, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4aQ9o3mwLf8g71RU8wyNNNCPdJSZhENIsqBjKUicL8BJXLqL2NMl0MlhjIRlv5Bpg0M3UZKuDlwhwLH8B3v2yNy/0, createdBy=11a82069421, createdName=136****3321, createdTime=Thu Jun 15 06:33:40 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210863, encodeId=ac4c210863a2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Thu Jun 15 06:02:42 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210818, encodeId=f20c210818b5, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Wed Jun 14 22:58:08 CST 2017, time=2017-06-14, status=1, ipAttribution=)]
    2017-06-15 Y—xianghai

    学习了新知识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2040519, encodeId=bda620405195d, content=<a href='/topic/show?id=2cb02845984' target=_blank style='color:#2F92EE;'>#儿童营养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28459, encryptionId=2cb02845984, topicName=儿童营养)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Wed Dec 13 04:27:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212437, encodeId=bdbb21243e30, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Jun 15 11:10:15 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211007, encodeId=51f321100eef, content=学习了。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Thu Jun 15 08:11:05 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210954, encodeId=d65621095440, content=学习了,日常日常息息相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, 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objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4aQ9o3mwLf8g71RU8wyNNNCPdJSZhENIsqBjKUicL8BJXLqL2NMl0MlhjIRlv5Bpg0M3UZKuDlwhwLH8B3v2yNy/0, createdBy=11a82069421, createdName=136****3321, createdTime=Thu Jun 15 06:33:40 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210863, encodeId=ac4c210863a2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Thu Jun 15 06:02:42 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210818, encodeId=f20c210818b5, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Wed Jun 14 22:58:08 CST 2017, time=2017-06-14, status=1, ipAttribution=)]
    2017-06-15 136****3321

    学习了分享了

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4aQ9o3mwLf8g71RU8wyNNNCPdJSZhENIsqBjKUicL8BJXLqL2NMl0MlhjIRlv5Bpg0M3UZKuDlwhwLH8B3v2yNy/0, createdBy=11a82069421, createdName=136****3321, createdTime=Thu Jun 15 06:33:40 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210863, encodeId=ac4c210863a2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Thu Jun 15 06:02:42 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210818, encodeId=f20c210818b5, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Wed Jun 14 22:58:08 CST 2017, time=2017-06-14, status=1, ipAttribution=)]
    2017-06-15 一个字-牛

    学习了谢谢分享

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Jun 15 07:06:43 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210951, encodeId=d8092109514a, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jun 15 07:04:27 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210900, encodeId=e264210900c5, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4aQ9o3mwLf8g71RU8wyNNNCPdJSZhENIsqBjKUicL8BJXLqL2NMl0MlhjIRlv5Bpg0M3UZKuDlwhwLH8B3v2yNy/0, createdBy=11a82069421, createdName=136****3321, createdTime=Thu Jun 15 06:33:40 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210863, encodeId=ac4c210863a2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Thu Jun 15 06:02:42 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210818, encodeId=f20c210818b5, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Wed Jun 14 22:58:08 CST 2017, time=2017-06-14, status=1, ipAttribution=)]
    2017-06-14 139****5926

    好文章学习了

    0