Diabetes care：新的糖尿病生物标记物！

2017-02-09 MedSci MedSci原创

糖尿病不同亚型的表征是一个动态的临床研究领域和讨论的活跃领域。近期，一项发表在杂志Diabetes care上的研究旨在确定神经内分泌自身抗原IA-2（ICA512）上新的抗原决定因素，并评估年轻人和成人糖尿病人群中针对新IA-2表位识别自身免疫性糖尿病的循环自身抗体。研究使用检测针对神经内分泌自身抗原IA-2（IA-2ec）的细胞外结构域的自身抗体的新生物标志物评价临床诊断为2型糖尿病（n =

糖尿病不同亚型的表征是一个动态的临床研究领域和讨论的活跃领域。

近期，一项发表在杂志Diabetes care上的研究旨在确定神经内分泌自身抗原IA-2（ICA512）上新的抗原决定因素，并评估年轻人和成人糖尿病人群中针对新IA-2表位识别自身免疫性糖尿病的循环自身抗体。

研究使用检测针对神经内分泌自身抗原IA-2（IA-2ec）的细胞外结构域的自身抗体的新生物标志物，以此评价临床诊断为2型糖尿病（n = 258;糖尿病持续时间：0.01-31年）的患者。同时也在新诊断为1型糖尿病患者（n = 150;糖尿病持续时间：0.04-0.49年）中评估IA-2ec自身抗体的比例。此外，也测定了IA-2（细胞内结构域），GAD65和锌转运蛋白8自身抗体。

此项研究结果显示：在1型糖尿病患者中检测到IA-2ec自身抗体，令人惊讶地是，在5％的2型糖尿病患者中检测到没有对其它IA-2抗原表位或其它胰岛自身抗原的血清学应答。

研究者们还通过刺激来自1型糖尿病患者以及HLA匹配的健康受试者（n = 13）的外周血单核细胞（n = 18）评估IA-2ec-衍生肽引发CD4 + T细胞应答的能力（使用多肽和肽/ DQ8特异性四聚体染色），以此观察与IA-2ec内先前未报告的表位的疾病相关反应。

研究者们开发了一种新的抗体生物标志物识别IA-2的N端新型抗原决定簇。可以在1型糖尿病患者中检测到IA-2ec自身抗体，并且存在于常规胰岛自身抗体测试中2型糖尿病表型阴性的成年自身免疫患者的亚型中。

原始出处：
Acevedo-Calado M, James EA, Morran MP, et al. Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development. Diabetes Care. 2017 Feb 7. pii: dc161527.

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2017-06-07 木头人513

#Diabetes#

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2017-03-24 ms9608593228839890

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2018-01-18 wjywjy

#标记物#

29 0
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2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175261, encodeId=59071e526198, content=自身抗原。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee471989203, createdName=墨尔, createdTime=Fri Feb 10 00:18:43 CST 2017, time=2017-02-10, status=1, ipAttribution=)]
2017-03-29 ms5439512287675881

#BET#

23 0
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2017-02-18 ylzr123

好文，值得点赞，值得拥有，值得收藏！

58 0
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2017-02-11 ylzr123

好文，值得点赞，值得拥有，值得收藏！

55 0
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2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175261, encodeId=59071e526198, content=自身抗原。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee471989203, createdName=墨尔, createdTime=Fri Feb 10 00:18:43 CST 2017, time=2017-02-10, status=1, ipAttribution=)]
2017-02-11 hbwxf

#生物标记物#

28 0
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encodeId=d540134534196, content=<a href='/topic/show?id=8907693e0fa' target=_blank style='color:#2F92EE;'>#生物标记#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69370, encryptionId=8907693e0fa, topicName=生物标记)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=278f2500221, createdName=12498fa0m11暂无昵称, createdTime=Sat Feb 11 12:12:00 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175546, encodeId=3bff1e554626, content=第一时间学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKJtqC6MEyItFUhsicbHLNTpicWaE6nx3QyIX0otTfAe10erLyEmSqo4pRmak0byqtbrrGCLdh5tR2g/0, createdBy=87451701570, createdName=好医生向大医精诚努力, createdTime=Sat Feb 11 10:32:52 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175261, encodeId=59071e526198, content=自身抗原。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee471989203, createdName=墨尔, createdTime=Fri Feb 10 00:18:43 CST 2017, time=2017-02-10, status=1, ipAttribution=)]
2017-02-11 12498fa0m11暂无昵称

#生物标记#

35 0
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topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Mar 29 11:12:00 CST 2017, time=2017-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176709, encodeId=d40a1e6709ea, content=好文，值得点赞，值得拥有，值得收藏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Feb 18 07:06:44 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175612, encodeId=f1bb1e561250, content=好文，值得点赞，值得拥有，值得收藏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Feb 11 17:29:32 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349916, encodeId=7ab6134991672, content=<a href='/topic/show?id=3a59693e129' target=_blank style='color:#2F92EE;'>#生物标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69371, encryptionId=3a59693e129, topicName=生物标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Feb 11 12:12:00 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345341, encodeId=d540134534196, content=<a href='/topic/show?id=8907693e0fa' target=_blank style='color:#2F92EE;'>#生物标记#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69370, encryptionId=8907693e0fa, topicName=生物标记)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=278f2500221, createdName=12498fa0m11暂无昵称, createdTime=Sat Feb 11 12:12:00 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175546, encodeId=3bff1e554626, content=第一时间学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKJtqC6MEyItFUhsicbHLNTpicWaE6nx3QyIX0otTfAe10erLyEmSqo4pRmak0byqtbrrGCLdh5tR2g/0, createdBy=87451701570, createdName=好医生向大医精诚努力, createdTime=Sat Feb 11 10:32:52 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175261, encodeId=59071e526198, content=自身抗原。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee471989203, createdName=墨尔, createdTime=Fri Feb 10 00:18:43 CST 2017, time=2017-02-10, status=1, ipAttribution=)]
2017-02-11 好医生向大医精诚努力

第一时间学习了

64 0
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createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Mar 24 04:12:00 CST 2017, time=2017-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904454, encodeId=d6fe1904454bc, content=<a href='/topic/show?id=b8aa619690e' target=_blank style='color:#2F92EE;'>#标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61969, encryptionId=b8aa619690e, topicName=标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Thu Jan 18 15:12:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759856, encodeId=3ed81e5985620, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Mar 29 11:12:00 CST 2017, time=2017-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176709, encodeId=d40a1e6709ea, content=好文，值得点赞，值得拥有，值得收藏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Feb 18 07:06:44 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175612, encodeId=f1bb1e561250, content=好文，值得点赞，值得拥有，值得收藏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Feb 11 17:29:32 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349916, encodeId=7ab6134991672, content=<a href='/topic/show?id=3a59693e129' target=_blank style='color:#2F92EE;'>#生物标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69371, encryptionId=3a59693e129, topicName=生物标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Feb 11 12:12:00 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345341, encodeId=d540134534196, content=<a href='/topic/show?id=8907693e0fa' target=_blank style='color:#2F92EE;'>#生物标记#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69370, encryptionId=8907693e0fa, topicName=生物标记)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=278f2500221, createdName=12498fa0m11暂无昵称, createdTime=Sat Feb 11 12:12:00 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175546, encodeId=3bff1e554626, content=第一时间学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKJtqC6MEyItFUhsicbHLNTpicWaE6nx3QyIX0otTfAe10erLyEmSqo4pRmak0byqtbrrGCLdh5tR2g/0, createdBy=87451701570, createdName=好医生向大医精诚努力, createdTime=Sat Feb 11 10:32:52 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=175261, encodeId=59071e526198, content=自身抗原。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee471989203, createdName=墨尔, createdTime=Fri Feb 10 00:18:43 CST 2017, time=2017-02-10, status=1, ipAttribution=)]
2017-02-10 墨尔

自身抗原。

48 0

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Diabetes care：新的糖尿病生物标记物！

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