J Hypertens:尿酸与超重和肥胖青少年心血管代谢危险因素相关!

2018-06-21 xing.T MedSci原创

由此可见,该研究发现尿酸与血压、胰岛素和甘油三酯呈正相关。随着尿酸水平的增加,代谢危险因素有所聚集,而血压升高是不常出现的危险因素。进一步的研究需要评估尿酸和心血管代谢危险因素之间的联系。

观察性研究表明高水平的血尿酸与心血管疾病的风险有关。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,该研究的目的是探究尿酸与超重和中度肥胖青年个体心血管代谢危险因素及其聚集程度之间的关系。

该研究纳入了333名高加索受试者(149名女性),年龄从5岁到18岁,这些受试者接受了超值/肥胖评估。此外,还测量了受试者的人体参数、诊室和24小时血压和代谢指标,包括HDL胆固醇、甘油三酯、胰岛素、HOMA指数和尿酸水平。

研究人员发现男童尿酸水平明显高于女生。尿酸与诊室、日间和夜间SBP、胰岛素和甘油三酯呈显著正相关。当男孩和女孩按照性别特异性尿酸三分位数分组时,BMI、BMI的Z评分和腰围、空腹胰岛素和HOMA指数逐渐增加。在男孩中,诊室和门诊SBP也可以观察到这样的变化。同样,异常代谢危险因素的数量也随着尿酸值的增加而增加,代谢组分的数量越多尿酸值越高。在多元回归分析中,尿酸与男性、腰围、诊室和夜间SBP、出生体重呈显著正相关。

由此可见,该研究发现尿酸与血压、胰岛素和甘油三酯呈正相关。随着尿酸水平的增加,代谢危险因素有所聚集,而血压升高是不常出现的危险因素。进一步的研究需要评估尿酸和心血管代谢危险因素之间的联系。

原始出处:

Lurbe, Empar,et al. Uric acid is linked to cardiometabolic risk factors in overweight and obese youths.Journal of Hypertension. 2018. https://journals.lww.com/jhypertension/Abstract/publishahead/Uric_acid_is_linked_to_cardiometabolic_risk.97442.aspx

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    2019-11-19 14692f92m26暂无昵称

    好,受益匪浅

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    2019-01-20 feather89
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createdBy=2bcd469, createdName=fengting3, createdTime=Sat May 04 02:57:00 CST 2019, time=2019-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326225, encodeId=054c32622541, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Jun 22 23:53:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326162, encodeId=63ee32616224, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jun 21 18:35:00 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Jun 21 21:51:44 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325898, encodeId=d5c7325898ad, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Jun 21 19:22:02 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325892, encodeId=361632589280, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jun 21 18:35:00 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-22 惠映实验室

    学习了.谢谢分享.

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Jun 21 21:51:44 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325898, encodeId=d5c7325898ad, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Jun 21 19:22:02 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325892, encodeId=361632589280, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jun 21 18:35:00 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-22 一天没事干

    很好的学习机会

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jun 21 18:35:00 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-22 张新亮1853311252142e2fm

    好文献学习了

    0

  8. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Fri Jun 22 19:32:50 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326042, encodeId=cc2e3260427c, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Jun 22 07:15:51 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325918, encodeId=c66932591845, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Jun 21 21:51:44 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325898, encodeId=d5c7325898ad, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Jun 21 19:22:02 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325892, encodeId=361632589280, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jun 21 18:35:00 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-21 changjiu

    谢谢分享学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=375531, encodeId=82793e5531fa, content=好,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6345149579, createdName=14692f92m26暂无昵称, createdTime=Tue Nov 19 13:10:23 CST 2019, time=2019-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727386, encodeId=4e141e2738666, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Jan 20 02:57:00 CST 2019, time=2019-01-20, status=1, ipAttribution=), 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createdBy=2bcd469, createdName=fengting3, createdTime=Sat May 04 02:57:00 CST 2019, time=2019-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326225, encodeId=054c32622541, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Jun 22 23:53:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326162, encodeId=63ee32616224, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Jun 21 21:51:44 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325898, encodeId=d5c7325898ad, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Jun 21 19:22:02 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325892, encodeId=361632589280, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jun 21 18:35:00 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-21 131****1460

    学习了受益匪浅

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jun 21 18:35:00 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-21 orangesking

    0

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