J Occup Environ Med:汽车尾气更容易使儿童发生DNA损伤

2017-05-25 tulip1999 来宝网

众所周知,空气污染对每个人都有害,但一项最新研究发现,空气污染对年轻人尤其危险。暴露于与交通相关污染的儿童和青少年容易产生DNA损伤,称为端粒缩短。



【研究表明,交通相关污染与儿童DNA损伤有关】众所周知,空气污染对每个人都有害,但一项最新研究发现,空气污染对年轻人尤其危险。暴露于与交通相关污染的儿童和青少年容易产生DNA损伤,称为端粒缩短。

《医学新闻》报告,端粒是DNA染色体末端的一段重复片段,保护染色体末端不损坏。它们的功能就像在鞋带末端的绳花,使整根鞋带不容易损坏。随着年龄增长,端粒不断缩短——已发现该过程与一些年龄相关性疾病有关。

根据科学日报的一份报告,已有初步研究显示,年轻的哮喘患者也表现出端粒缩短的迹象。这项最新研究包括了居住在弗雷斯诺及加利福尼亚的14名儿童和青少年,这两个城市是全美国污染最严重的两个城市。

研究人员分析了端粒缩短与机动车尾气中普遍存在的空气污染物多环芳烃(PAHs)之间的关系。他们发现,随着接触多环芳烃(PAHs)越多,端粒长度减少越明显。

研究发现,那些饱受哮喘折磨的人比那些非哮喘患者更经常接触更高浓度的多环芳烃(PAHs)。在研究人员对可能会影响到哮喘和端粒长度的年龄、性别和种族等相关因素进行调整之后,多环芳烃(PAHs)暴露与端粒缩短之间的联系仍然存在。

曾经认为儿童的端粒缩短调节机制与成年人不太一样,所以在同样接触机动车尾气的情况下,他们往往比年龄较大的人更容易因为空气污染受到伤害。

研究人员在论文中写道:“我们的研究结果表明,端粒长度有可能作为环境暴露和/或慢性炎症导致的DNA损伤的生物标志物。”

这项研究成果发表在《职业与环境医学杂志》上。

原始出处:

Eunice Y. Lee, Jue Lin, Elizabeth M. Noth, et al. Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study. Journal of Occupational and Environmental Medicine. 59(5):446–452, MAY 2017.

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    2017-05-27 Actor

    如此说来,孩子应该多戴口罩?

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    2017-05-27 zhaojie88
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