HEART:中国学者证实ERP与动脉粥样硬化危险因素的长期预后相关性

2017-06-07 MedSci MedSci原创

既往研究表明早期复极化模式(ERP)在无结构性心脏病患者中与突发心源性死亡(SCD)相关。然而,尚未有研究证实ERP在动脉粥样硬化性心脏病高危人群中的预后价值。

既往研究表明早期复极化模式(ERP)在无结构性心脏病患者中与突发心源性死亡(SCD)相关。然而,尚未有研究证实ERP在动脉粥样硬化性心脏病高危人群中的预后价值。近日,在国际心血管权威杂志《HEART》上发表了一篇中国学者探索ERP与动脉粥样硬化危险因素的长期预后相关性的研究。

本研究前瞻性地评估了ERP在18231例基于社区的动脉粥样硬化高危人群(男性占49.3%,平均年龄64.0岁)中的预后意义,平均随访时间为7.6年。研究结果显示,相比于没有ERP的患者,出现有ERP患者的SCD发生风险显着增高(HR:1.91;95% Cl:1.30-2.82),因冠心病死亡的风险也显着增加(HR:1.35;95% CI:1.22-1.50)。ERP与非冠心病源性死亡没有相关性。伴有高波幅J波、下凹波形、水平或下降的ST段的J波模式的ERP发生SCD的风险更高。此外,ERP在与动脉粥样硬化性心脏病高风险人群中每10万人年的绝对风险额外增加52.3例SCD相关联。

在动脉粥样硬化性心脏病高风险人群中,ERP能显著增加突发心源性死亡、冠心病源性死亡和其他死亡的风险。

原始出处:

Doi:http://dx.doi.org/10.1136/heartjnl-2016-310259

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    2017-06-09 zhaojie88
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    2017-06-09 slcumt

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