ACC 2015:住院早期利尿剂应答不佳与急性心衰患者转归较差(ASCEND-HF)

2015-03-14 MedSci MedSci原创

今天召开的美国心脏病学会年会(ACC2015)上发布的一项研究表明,急性心衰患者住院早期利尿剂应答不佳与血压较低、肾功能受损、尿量较少以及死亡在再住院风险升高具有相关性。奈西立肽对利尿剂应答影响呈中性。 急性心衰患者仍在继续应用奈西立肽。此项研究共纳入4379例急性心衰患者,并评估了从住院至入院后48小时的利尿剂应答,以及奈西立肽对入院早期利尿剂应答的影响。以每40mg呋塞米或等量利尿剂体重

今天召开的美国心脏病学会年会(ACC2015)上发布的一项研究表明,急性心衰患者住院早期利尿剂应答不佳与血压较低、肾功能受损、尿量较少以及死亡在再住院风险升高具有相关性。奈西立肽对利尿剂应答影响呈中性。

急性心衰患者仍在继续应用奈西立肽。此项研究共纳入4379例急性心衰患者,并评估了从住院至入院后48小时的利尿剂应答,以及奈西立肽对入院早期利尿剂应答的影响。以每40mg呋塞米或等量利尿剂体重减轻定义利尿剂应答。

结果显示,平均利尿剂应答为-0.42kg/40mg呋塞米。利尿剂应答不良者血压较低,糖尿病患病率更高,长期应用袢利尿剂,基线肾功能较差,并且尿量较少(P<0.01)。

奈西立肽与利尿剂应答无相关性。利尿剂应答良好与30天全因死亡或再住院(OR 0.44;P<0.001)以及30天心源性死亡或再住院(OR 0.52;P<0.001)风险显著降低具有独立相关性。

敏感性分析显示,利尿剂应答与肾功能较差具有相关性,奈西立肽治疗则与之无显著相关性。

英文链接:Diuretic Response in Acute Heart Failure: An Analysis from ASCEND-HF

原始出处:

DeVore AD, Hasselblad V, Mentz RJ, O'Connor CM, Armstrong PW, McMurray JJ, Ezekowitz JA, Tang WH, Starling RC, Voors AA, Califf RM, Hernandez AF.Loop diuretic dose adjustments after a hospitalization for heart failure: insights from ASCEND-HF. Eur J Heart Fail. 2015 Mar;17(3):340-6

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    2015-04-23 quxin068
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1938468, encodeId=dabf193846870, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Apr 23 23:11:00 CST 2015, time=2015-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271926, encodeId=830512e1926d6, content=<a href='/topic/show?id=573332291bd' target=_blank style='color:#2F92EE;'>#利尿剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32291, encryptionId=573332291bd, topicName=利尿剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Mon Mar 16 00:11:00 CST 2015, time=2015-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325010, encodeId=4f11132501042, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Mon Mar 16 00:11:00 CST 2015, time=2015-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1359771, encodeId=e3f71359e717f, content=<a href='/topic/show?id=5aa95229085' target=_blank style='color:#2F92EE;'>#急性心衰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52290, encryptionId=5aa95229085, topicName=急性心衰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 16 00:11:00 CST 2015, time=2015-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373284, encodeId=fe7b13e328430, content=<a href='/topic/show?id=2fd051939ab' target=_blank style='color:#2F92EE;'>#心衰患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51939, encryptionId=2fd051939ab, topicName=心衰患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Mar 16 00:11:00 CST 2015, time=2015-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18325, encodeId=f60518325b5, content=利尿剂无应答没有尿量的指标, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=drhqh240, createdTime=Sat Mar 14 21:07:00 CST 2015, time=2015-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18292, encodeId=0fad1829240, content=有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=hbwang006, createdTime=Sat Mar 14 11:06:00 CST 2015, time=2015-03-14, status=1, ipAttribution=)]
    2015-03-14 drhqh240

    利尿剂无应答没有尿量的指标

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1938468, encodeId=dabf193846870, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Apr 23 23:11:00 CST 2015, time=2015-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271926, encodeId=830512e1926d6, content=<a href='/topic/show?id=573332291bd' target=_blank style='color:#2F92EE;'>#利尿剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32291, encryptionId=573332291bd, topicName=利尿剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Mon Mar 16 00:11:00 CST 2015, time=2015-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325010, encodeId=4f11132501042, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Mon Mar 16 00:11:00 CST 2015, time=2015-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1359771, encodeId=e3f71359e717f, content=<a href='/topic/show?id=5aa95229085' target=_blank style='color:#2F92EE;'>#急性心衰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52290, encryptionId=5aa95229085, topicName=急性心衰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 16 00:11:00 CST 2015, time=2015-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373284, encodeId=fe7b13e328430, content=<a href='/topic/show?id=2fd051939ab' target=_blank style='color:#2F92EE;'>#心衰患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51939, encryptionId=2fd051939ab, topicName=心衰患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Mar 16 00:11:00 CST 2015, time=2015-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18325, encodeId=f60518325b5, content=利尿剂无应答没有尿量的指标, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=drhqh240, createdTime=Sat Mar 14 21:07:00 CST 2015, time=2015-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18292, encodeId=0fad1829240, content=有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=hbwang006, createdTime=Sat Mar 14 11:06:00 CST 2015, time=2015-03-14, status=1, ipAttribution=)]
    2015-03-14 hbwang006

    有道理

    0

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