Diabetologia:使用HOMA-IR诊断非酒精性脂肪肝

2017-10-23 MedSci MedSci原创

最近欧洲的非酒精性脂肪性肝指南(NAFLD)要求设定HOMA-IR的参考值。近日,国际杂志 《Diabetologia》上在线发表一项关于基于人群和实验室间的使用HOMA-IR诊断非酒精性脂肪肝的研究。在本研究中,研究人员旨在确定:(1)两个基于群体的队列中正常HOMA-IR的上限;(2)对应于NAFLD的HOMA-IR;(3)rs738409的性别和PNPLA3基因型对HOMA-IR的影响; 和

最近欧洲的非酒精性脂肪性肝指南(NAFLD)要求设定HOMA-IR的参考值。近日,国际杂志 《Diabetologia》上在线发表一项关于基于人群和实验室间的使用HOMA-IR诊断非酒精性脂肪肝的研究。在本研究中,研究人员旨在确定:(1)两个基于群体的队列中正常HOMA-IR的上限;(2)对应于NAFLD的HOMA-IR;(3)rs738409的性别和PNPLA3基因型对HOMA-IR的影响; 和(4)HOMA-IR中的实验室间差异。 研究人员在两个基于人群的队列(FINRISK 2007 [ n=5024]中确定了健康人,在芬兰预防2型糖尿病计划[FIN-D2D;n=2849])中定义HOMA-IR的上95位百分位数。健康认定的标准为正常空腹血糖水平,无过量使用酒精,无已知疾病,无使用任何药物的非肥胖个体。在368名非糖尿病患者(NAFLD为35%)中测定NAFLD(肝脂肪≥5.56%,基于达拉斯心脏研究)的最佳HOMA-IR截止值,其肝脏脂肪使用质子磁共振波谱法1 H-MRS)测定。对来自七个欧洲实验室十个个体的样品中同时分析HOMA-IR。 在FINRISK(n =1167)和F

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    2017-10-31 智慧医人
  5. [GetPortalCommentsPageByObjectIdResponse(id=1673336, encodeId=b21316e3336db, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Sun Apr 15 14:22:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760261, encodeId=a79d1e602616b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Feb 20 16:22:00 CST 2018, time=2018-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1980463, encodeId=18cb1980463eb, content=<a href='/topic/show?id=099f9548ed7' target=_blank style='color:#2F92EE;'>#酒精性脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95487, encryptionId=099f9548ed7, topicName=酒精性脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Mon Sep 24 12:22:00 CST 2018, time=2018-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638104, encodeId=28d21638104d3, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Oct 31 19:22:00 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676357, encodeId=c4dc16e63578d, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18c27357544, createdName=Tommy1958, createdTime=Thu Jun 21 18:22:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255406, encodeId=d83325540642, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Mon Oct 23 19:59:32 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255390, encodeId=408825539032, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Oct 23 19:34:19 CST 2017, time=2017-10-23, status=1, ipAttribution=)]
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    2017-10-23 changjiu

    学习了.谢谢

    0

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    2017-10-23 惠映实验室

    学习了.谢谢

    0

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