Sci Rep:非小细胞肺癌患者全身治疗对脑转移的影响

2019-12-15 xiangting MedSci原创

总之,接受TT作为一线治疗患者的脑转移总累积发生率明显高于CC治疗患者。

为了比较晚期非小细胞肺癌NSCLC)使用全身细胞毒化疗(CC)与靶向治疗(TT)脑转移的发生率,研究人员进行了一项大规模、回顾性、全国队列研究。

人口数据摘自201111日至20161130日的韩国健康保险审查与评估服务数据库。在29,174例接受全身治疗的新诊断IIIBIVNSCLC患者中,研究人员调查了初始和随后的脑转移发生率。此外,22458例初始无脑转移的患者根据给予的全身治疗比较了随后脑转移的总累积发生率。

总共1,126例患者(5.0%)随后发生了脑转移。TT组的脑转移总累积发生率明显高于CC组(1年累积发生率:8.7vs. 3.8%;3年累积发生率:17.2vs. 5.0%; P<0.001)。年龄小、女性、一线TT治疗是随后发生脑转移的重要危险因素。

总之,接受TT作为一线治疗患者的脑转移总累积发生率明显高于CC治疗患者。

原始出处:

Jung Soo Lee. The impact of systemic treatment on brain metastasis in patients with non-small-cell lung cancer: A retrospective nationwide population-based cohort study. Sci Rep. 10 December 2019.

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