J Diabetes Invest:采用DPP4抑制剂降血糖,注意这一点可能是成败的关键!

2017-12-05 sunshine2015 来宝网

根据11月24日在线发表在糖尿病调查上的一项研究,对于2型糖尿病(T2D)患者,脂肪摄入可能会导致二肽基肽酶-4抑制剂(DPP4i)单药治疗中血红蛋白A1c(HbA1c)水平的下降。

脂肪摄入影响糖化血红蛋白下降效果】根据11月24日在线发表在糖尿病调查上的一项研究,对于2型糖尿病(T2D)患者,脂肪摄入可能会导致二肽基肽酶-4抑制剂(DPP4i)单药治疗中血红蛋白A1c(HbA1c)水平的下降

日本神户关西电力医学研究所的Kuwata博士及其同事研究了DPP4i单药治疗中HbA1c降低效应恶化与T2D个体大量营养素摄入之间的相关性。开始和继续DPP4i单药治疗一年而不改变处方的参与者被分类为在DPP4i启动后0.5?1年期间维持HbA1c水平的患者(A组,HbA1c <0.4%; 53个人) HbA1c水平升高(B组,ΔHbA1c≥0.4%; 10人)。

研究人员发现,B组具有显着较高的ΔHbA1c,体重和脂肪摄入量,特别是饱和脂肪和单不饱和脂肪。碳水化合物和蛋白质的摄入量在各组之间是相似的。脂肪摄入量,尤其是饱和脂肪摄入量与多元回归分析中的ΔHbA1c有显着的相关性。

作者写道:“饮食习惯,特别是饱和脂肪摄入量,可能会促进DPP4i单药治疗中HbA1c降低效应的恶化。”

几位作者披露了与制药行业的财务关系。

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    2018-01-06 jklm09
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    2017-12-07 oliver176
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    2017-12-05 天地飞扬

    谢谢分享.学习了!

    0

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很多人硬是下不了决心去狠狠甩掉肚子上多余的脂肪。随着癌症的不断深入研究,人们发现了肥胖和多种癌症之间都有着暧昧的关系,比如乳腺癌、结肠癌、卵巢癌以及前列腺癌。然而不单单是这些,近期,一篇研究首次发现,多余的脂肪代谢掉化疗药物从而帮助癌细胞生长!

Metabolism:肉桂,能助你燃烧脂肪!

美国密歇根大学生命科学研究所(LSI)的一项新研究发现,肉桂皮这种常用的香料或许能够对抗肥胖。