Stroke:头痛早期,脑CT排除蛛网膜下腔出血敏感性较高

2016-07-25 phylis 译 MedSci原创

背景:新的证据表明早期脑部电脑断层扫描(CT)高灵敏度带来的问题,即CT诊断阴性后,必须进行腰椎穿刺诊断自发性蛛网膜下腔出血的(SAH)。研究者旨在确定头痛开始6小时内脑CT排除SAH的敏感性。方法:对Ovid MEDLINE, Ovid EMBASE, Web of Science和Scopus进行全面的文献检索,研究者进行了一项荟萃分析。纳入自发性蛛网膜下腔出血史的患者,在症状开始6小时内使用

背景:新的证据表明早期脑部电脑断层扫描(CT)高灵敏度带来的问题,即CT诊断阴性后,必须进行腰椎穿刺诊断自发性蛛网膜下腔出血的(SAH)。研究者旨在确定头痛开始6小时内脑CT排除SAH的敏感性。

方法:对Ovid MEDLINE, Ovid EMBASE, Web of Science和Scopus进行全面的文献检索,研究者进行了一项荟萃分析。纳入自发性蛛网膜下腔出血史的患者,在症状开始6小时内使用新一代的多排螺旋CT扫描的原始研究。研究以系统综述和荟萃分析作为优先报告项目(PRISMA)。

结果:总共对882个论文进行了审查,5篇论文符合纳入标准,包括8907例患者。6小时内脑CT未显示蛛网膜下腔出血(发生率1.46/1000)。CT的总敏感性为0.987(95%CI,0.971-0.994),特异性为0.999(95%CI,0.993-1.0)。阴性CT总似然比(likelihood Ratio, LR)为0.010(95%CI,0.003-0.034)。

结论:出现剧烈头痛和神经系统检查正常的患者,头痛6小时内脑CT排除动脉瘤性蛛网膜下腔出血是极其敏感的。

原始出处:

Dubosh NM, Bellolio MF, et al. Sensitivity of Early Brain Computed Tomography to Exclude Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis. Stroke. 2016 Mar


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    2016-07-26 lujian
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    2016-10-11 ylzr123

    好文值得点赞!继续关注学习。

    0

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