J Investig Clin Dent:吸烟与不吸烟的牙周炎患者唾液中肝细胞生长因子的水平如何

2017-12-19 MedSci MedSci原创

肝细胞生长因子(HGF)是一种作用广泛的多功能细胞因子,在牙周病(PD)发展中起着重要作用。已知吸烟可明显增加PD进展的风险。因此,本研究旨在评估伴慢性牙周炎(CP)的非吸烟者和吸烟者唾液中HGF的水平,并比较其治疗前后的水平。研究共招募了75名参与者,分为三组:第一组包括25名健康参与者,第二组包括25名伴CP的不吸烟者,第三组包括25名伴CP的吸烟者。通过酶联免疫吸附测定估计唾液中HGF的水平

肝细胞生长因子(HGF)是一种作用广泛的多功能细胞因子,在牙周病(PD)发展中起着重要作用。已知吸烟可明显增加PD进展的风险。因此,本研究旨在评估伴慢性牙周炎(CP)的非吸烟者和吸烟者唾液中HGF的水平,并比较其治疗前后的水平。

研究共招募了75名参与者,分为三组:第一组包括25名健康参与者,第二组包括25名伴CP的不吸烟者,第三组包括25名伴CP的吸烟者。通过酶联免疫吸附测定估计唾液中HGF的水平,并与治疗前后的临床参数进行相关性分析。

结果显示,非吸烟者和吸烟者唾液中HGF的水平均显著高于对照组。牙周非手术治疗(NSPT)后吸烟者和非吸烟者唾液中HGF的水平显著降低。

综上所述,该研究结果表明,唾液中HGF的水平与PD进展和吸烟状态呈正相关。NSPT后HGF的水平显著降低。因此,在一定程度上,我们可以认为HGF在PD的进展中起作用,并且可以用作检测疾病活性的诊断性生物标志物。唾液HGF的水平也可用于监测对牙周治疗的反应。

原始出处:

Guru S, Sam SE, et al., Comparative evaluation of salivary hepatocyte growth factor in smokers and non-smokers with chronic periodontitis. J Investig Clin Dent. 2017 Nov 29. doi: 10.1111/jicd.12306.

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    2018-05-05 xjy02
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