Sci Rep:MIC-1作为一个基于血清的前列腺癌预测因子的相关性研究

2017-12-18 AlexYang MedSci原创

为了减少在不同的研究中,关于巨噬细胞抑制因子-1(MIC-1)在前列腺癌(PC)、良性前列腺增生(BPH)和健康对照中的表达水平中相互不同观察结果的争议,最近,有研究人员设计了一个双盲的研究。研究包括了240例来自PC、BPH和HC病人的血清。研究人员利用蛋白免疫印迹技术(WB)和基于ELISA技术的方法评估了MIC-1在PC、BPH和HC中的表达水平。研究发现,WB和ELISA技术评估阐释了MI

为了减少在不同的研究中,关于巨噬细胞抑制因子-1(MIC-1)在前列腺癌(PC)、良性前列腺增生(BPH)和健康对照中的表达水平中相互不同观察结果的争议,最近,有研究人员设计了一个双盲的研究。研究包括了240例来自PC、BPH和HC病人的血清。研究人员利用蛋白免疫印迹技术(WB)和基于ELISA技术的方法评估了MIC-1在PC、BPH和HC中的表达水平。

研究发现,WB和ELISA技术评估阐释了MIC-1的表达水平在PC患者中要显著高于HC或者BPH患者。回归分析表明,MIC-1 vs PSA之间和MIC-1 vs GS(r=0.7; p<0.001))具有显著的相关性(r=0.09; p<0.001)。利用判别式预测可能性的ROC分析表明,MIC-1要比PSA更好。更多的是,MIC-1和PSA的组合使用使得HC与BPH+PC的差异化AUC为99.1%,HC与BPH的差异化AUC为97.9%,HC与PC的差异化AUC为98.6%,BPH与PC的差异化AUC为96.7%。最后,研究人员指出,与BPH和HC相比,MIC-1在PC中表达的增加与PC报告中MIC-1的超表达一致,解决了其他研究中相互矛盾结果的问题。

原始出处:

Navneeta Bansal, Deepak Kumar, Ashish Gupta et al. Relevance of MIC-1 in the Era of PSA as a Serum Based Predictor of Prostate Cancer: A Critical Evaluation. Sci Rep. 04 DEC 2017.

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    2017-12-20 1e145228m78(暂无匿称)

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    2017-12-19 131****2916

    不错的文章值得推荐

    0

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    2017-12-19 137****9095

    henhao

    0

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    2017-12-19 wzb521zf

    一起学习学习

    0

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    2017-12-18 changjiu

    谢谢.学习了

    0

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