Gut:低聚半乳糖缓解铁元素对肠道微生物的不良影响

2017-08-05 海北 MedSci原创

含有铁的微量元素粉末能够帮助非洲婴儿减少贫血的发生。但是,人们发现,高剂量铁元素的摄入(12.5mg/day)对于婴儿体内的肠道微生物会有影响。其会减少双歧杆菌和乳酸菌的数量,增加肠道病原菌的数量,增加婴儿腹泻以及呼吸道感染的风险。

含有铁的微量元素粉末能够帮助非洲婴儿减少贫血的发生。但是,人们发现,高剂量铁元素的摄入(12.5mg/day)对于婴儿体内的肠道微生物会有影响。其会减少双歧杆菌和乳酸菌的数量,增加肠道病原菌的数量,增加婴儿腹泻以及呼吸道感染的风险。 新型的微量元素粉末配方包括了益生元低聚半乳糖和低剂量高生物利用度的铁(5mg /天)。来自苏黎世联邦理工大学的研究人员评估了该配方的安全性和有效性。 在一个为期4个月的双盲对照实验中,研究人员将6.5-9.5个月的肯尼亚婴儿进行了随机分组,每天给婴儿摄入(1)不含铁的微量元素粉末(对照组);(2)含有5mg铁元素的微量元素粉末(Fe组);(3)含有5mg铁元素以及7.5g低聚半乳糖的微量元素粉末(FeGOS组)。 结果显示,和对照组相比,摄入铁元素的Fe组和FeGOS组婴儿的贫血发生率减少了50%。但是,和对照组相比,Fe组婴儿体内的双歧杆菌和乳杆菌的丰度降低,梭菌丰度升高,病原体的毒素和有害基因丰度上升,血浆肠道脂肪酸结合蛋白升高(这是肠细胞损伤的生物标志物),呼吸道感染的发生率升高。相反,FeGOS组和对照组比较没有显著的差异,FeGOS组中病原体毒素

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    2023-03-02 灿漫 来自北京

    学习

    0

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    2017-08-09 kalery

    学习了,好文章

    0

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    2017-08-07 minzju5058
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    2017-08-07 chshh83
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    2017-08-05 hhh678

    henhao

    0

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    2017-08-05 成恩

    筑底鞋驻地距

    0

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