Neurosurgery:脑出血后早期预防VTE现状调查

2018-02-25 杨中华 脑血管病及重症文献导读

深静脉血栓形成(DVT)和肺栓塞(PE)是脑出血患者致死和致残的主要原因。脑出血患者的静脉血栓栓塞(VTE)是缺血性卒中的四倍。脑出血后症状性VTE发生率为1-10%,无症状性VTE为20-80%。

深静脉血栓形成(DVT)和肺栓塞(PE)是脑出血患者致死和致残的主要原因。脑出血患者的静脉血栓栓塞(VTE)是缺血性卒中的四倍。脑出血后症状性VTE发生率为1-10%,无症状性VTE为20-80%。

按照AHA脑出血管理指南推荐所有患者都应该给予气压装置,出血停止1-4天内的高风险(比如卧床、偏瘫)患者应该给予低剂量皮下肝素或低分子肝素(LMWH)。但是目前缺乏脑出血后预防VTE的资料。2018年1月来自芝加哥的Laurel J. Cherian等在NEUROSURGERY上发表了他们的研究结果,他们利用跟着指南走(GWTG)卒中登记研究的数据验乞了脑出血后早期药物预防VTE的患者和医院特征。

该项观察性纳入了2009年1月到2013年9月间的脑出血患者,纳入标准包括1.住院前两天不能步行和/或非姑息治疗者;2.未被转运到其他急救护理单元;和3.出院前2天采取了VTE预防措施。VTE预防措施的分类1.机械性非药物预防或2.药物预防联合使用或未使用机械性预防措施。早期预防定义为住院2天内。

共纳入了来自1358家医院的74283例脑出血患者,前两天内其中7.9%早期使用了药物预防,89.4%采用了早期机械/非药物预防措施,2.6%未采取预防措施。60%的医院早期药物的患者比例小于9%。多变量分析显示以下因素与早期药物预防有关:女性,房颤糖尿病,冠脉、颈动脉和外周动脉病,既往缺血性卒中或TIA,医院床位超过500张,以及地域。

最终作者认为从全国范围看(美国),大部分脑出血患者采取了早期机械性VTE预防措施(非药物预防)。患者的合并症以及医院的特征比如地域决定了早期药物预防的使用率。

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    2018-08-09 chg121
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    2018-03-04 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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    2018-02-27 虈亣靌

    学习了.获益匪浅.感谢分享

    0

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    2018-02-27 lsndxfj
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    2018-02-26 yfjms

    学习

    0

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