Neurology：糖尿病与帕金森病！

2018-04-07 xing.T MedSci原创

由此可见，糖尿病可能促进帕金森样病变，而在帕金森病患者中，伴有糖尿病可诱导更严重的表型。

近日，神经病学领域权威取杂志Neurology上发表了一篇研究文章，研究人员旨在探讨糖尿病患者是否无帕金森病患者的帕金森样病变有关，并评估糖尿病对未进行治疗的早期帕金森病患者帕金森病理和临床进展标志的影响。

研究人员对25例帕金森病合并糖尿病患者、25例帕金森但无糖尿病患者、14例糖尿病但无帕金森病患者以及14例健康对照者（无糖尿病也无帕金森病）进行了比较。经连续2次空腹血糖测定超过126mL/dL证实为糖尿病的临床诊断。在36个月的随访期间，研究人员调查了患有帕金森病的人群明确糖尿病的发生是否与更快的运动进展或认知能力下降有关。

研究人员发现糖尿病与帕金森病患者较高的运动评分（P＜0.01）、较低的纹状体多巴胺转运体结合率（P＜0.05）、较高的tau蛋白水平（P＜0.05）有关。在无帕金森病的糖尿病患者中，与健康对照者相比，糖尿病与较低的纹状体多巴胺转运蛋白结合率（P＜0.05）和CSF中较高的tau蛋白（P＜0.05）和α-突触核蛋白（P＜0.05）水平相关。在帕金森病患者的COX生存分析中，糖尿病与运动进展更快（风险比=4.521，95%可信区间为1.468-13.926，P＜0.01）和认知下降（风险比=9.314，95%可信区间为1.164-74.519，P＜0.05）有关。

由此可见，糖尿病可能促进帕金森样病变，而在帕金森病患者中，伴有糖尿病可诱导更严重的表型。

原始出处：

Gennaro Pagano,et al. Diabetes mellitus and Parkinson disease.neurology.2018. https://doi.org/10.1212/WNL.0000000000005475

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2018-04-19 yinhl1978

#Neurol#

35 0
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2018-04-10 周周人

学习.

60 0
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2018-04-08 lofter

学习了感谢分享

63 0
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2018-04-08 小贝熊

糖尿病可能促进帕金森样病变.而在帕金森病患者中.伴有糖尿病可诱导更严重的表型.

57 0
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2018-04-07 131****1460

学习了受益匪浅

59 0
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2018-04-07 1ddf0692m34(暂无匿称)

学习了.谢谢分享

45 0
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2018-04-07 易水河

哲学上早就说了.事物都有相互联系的

29 0
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2018-04-07 神功盖世

阅

21 0
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2018-04-07 清风拂面

谢谢分享学习

20 0

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