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Blood：神经递质受体GABBR1直接调控造血干/祖细胞的增殖和功能

2020-09-17 QQY MedSci原创

神经递质受体造血干/祖细胞GABBR1
关注

造血系统和神经系统是通过骨髓（BM）壁龛细胞的神经支配而联系起来的。造血干/祖细胞(HSPCs)表达神经递质受体，如g-氨基丁酸(GABA) B型受体亚基1 (GABBR1)，提示HSPCs可以受GA

造血系统和神经系统是通过骨髓（BM）壁龛细胞的神经支配而联系起来的。造血干/祖细胞(HSPCs)表达神经递质受体，如g-氨基丁酸(GABA) B型受体亚基1 (GABBR1)，提示HSPCs可以受GABA等神经递质直接与GABBR1结合的调控。

Shao等人通过成像质谱分析(IMS)，发现内源性GABA分子在BM壁龛中的骨内膜附近区域富集。为了更好的理解GABBR1调节HSPCs的功能，Shao等人构建了一个组成性的Gabbr1敲除的小鼠模型。
 
通过分析发现，与野生型小鼠相比，Gabbr1敲除小鼠的HSPC数量显著减少。而且，在竞争性移植模型中，Gabbr1-/-造血干细胞(HSCs)重建经放射处理小鼠的能力减弱。
（Gabbr1-/-造血干细胞的增殖减弱，并伴有B细胞系扩增）

无论是在稳定还是应激状态下，Gabbr1-/-造血干细胞的增殖均减弱。克隆试验显示，几乎所有的Gabbr1-/-HSPC都处在一种缓慢或非循环状态。在体外共培养时，Gabbr1-/-HSPC产生的细胞总量少，而且伴有显著的分化缺陷和B细胞系扩增。

为了明确GABBR1激动剂是否可刺激人脐带血（UCB）HSPC，研究人员在将UCB HSPC移植到免疫缺陷小鼠之前，进行了简短的体外治疗，结果显示：与GABBR1拮抗剂或空白治疗相比，GABBR1激动剂治疗的HSPC的长期移植显著增加。

综上所述，本研究结果表明，GABBR1在HSPC增殖中的直接作用，GABBR1或可成为临床移植中改善HSPC移植预后的潜在靶点。

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    2020-09-23 gdsun

    #神经递质受体#

    0

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    2020-09-19 Nebula-Qin

    学习

    0

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    2020-09-19 zxxiang

    #神经递质#

    0

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    2020-09-19 俅侠

    #造血#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1724196, encodeId=e8301e2419661, content=<a href='/topic/show?id=ddd2e459363' target=_blank style='color:#2F92EE;'>#神经递质受体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74593, encryptionId=ddd2e459363, topicName=神经递质受体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74a733584701, createdName=gdsun, createdTime=Wed Sep 23 09:03:24 CST 2020, time=2020-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886732, encodeId=b70b886e3265, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Sat Sep 19 22:32:56 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468115, encodeId=3da814681154d, content=<a href='/topic/show?id=1ec7e4592aa' target=_blank style='color:#2F92EE;'>#神经递质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74592, encryptionId=1ec7e4592aa, topicName=神经递质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a506885657, createdName=zxxiang, createdTime=Sat Sep 19 12:03:24 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494750, encodeId=99d01494e50e5, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Sat Sep 19 12:03:24 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512482, encodeId=73d01512482bb, content=<a href='/topic/show?id=f802e4102cb' target=_blank style='color:#2F92EE;'>#祖细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74102, encryptionId=f802e4102cb, topicName=祖细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18310470858, createdName=12498636m52(暂无昵称), createdTime=Sat Sep 19 12:03:24 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886561, encodeId=11238865615c, content=GABBR1，不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/04/25/8871649dafdf47fc03870885c26f2c24.jpg, createdBy=a5b02015518, createdName=ShawYuan, createdTime=Sat Sep 19 06:55:39 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886191, encodeId=5b67886191a4, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Sep 17 22:04:36 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886175, encodeId=780e8861e59d, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29895178005, createdName=146ee7d0m91暂无昵称, createdTime=Thu Sep 17 21:24:37 CST 2020, time=2020-09-17, status=1, ipAttribution=)]
    2020-09-19 12498636m52(暂无昵称)

    #祖细胞#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1724196, encodeId=e8301e2419661, content=<a href='/topic/show?id=ddd2e459363' target=_blank style='color:#2F92EE;'>#神经递质受体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74593, encryptionId=ddd2e459363, topicName=神经递质受体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74a733584701, createdName=gdsun, createdTime=Wed Sep 23 09:03:24 CST 2020, time=2020-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886732, encodeId=b70b886e3265, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Sat Sep 19 22:32:56 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468115, encodeId=3da814681154d, content=<a href='/topic/show?id=1ec7e4592aa' target=_blank style='color:#2F92EE;'>#神经递质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74592, encryptionId=1ec7e4592aa, topicName=神经递质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a506885657, createdName=zxxiang, createdTime=Sat Sep 19 12:03:24 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494750, encodeId=99d01494e50e5, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Sat Sep 19 12:03:24 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512482, encodeId=73d01512482bb, content=<a href='/topic/show?id=f802e4102cb' target=_blank style='color:#2F92EE;'>#祖细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74102, encryptionId=f802e4102cb, topicName=祖细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18310470858, createdName=12498636m52(暂无昵称), createdTime=Sat Sep 19 12:03:24 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886561, encodeId=11238865615c, content=GABBR1，不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/04/25/8871649dafdf47fc03870885c26f2c24.jpg, createdBy=a5b02015518, createdName=ShawYuan, createdTime=Sat Sep 19 06:55:39 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886191, encodeId=5b67886191a4, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Sep 17 22:04:36 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886175, encodeId=780e8861e59d, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=29895178005, createdName=146ee7d0m91暂无昵称, createdTime=Thu Sep 17 21:24:37 CST 2020, time=2020-09-17, status=1, ipAttribution=)]
    2020-09-19 ShawYuan

    GABBR1，不错

    0

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    2020-09-17 wxl882001

    了解

    0

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    2020-09-17 146ee7d0m91暂无昵称

    1

    0

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