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Quantitation of gamma-Glutamylcysteine-Formaldehyde Conjugate in Formaldehyde- and Oxidative Stress-Exposed Cells by Liquid Chromatography-Tandem Mass Spectrometry

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (7)

Humans are constantly exposed to formaldehyde (FA) of both exogenous and endogenous sources, and FA exposure is associated with the development of man......

Infection with Human Papillomavirus 18 Promotes Alkylating Agent-Induced Malignant Transformation in a Human Esophageal Cell Line

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 24 (8)

The relationship between human papillomavirus (HPV) and esophageal cancer (EC) has been controversial, which may be caused by the difference in geogra......

Prediction of the Blood-Brain Barrier (BBB) Permeability of Chemicals Based on Machine-Learning and Ensemble Methods

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (6)

The ability of chemicals to enter the blood-brain barrier (BBB) is a key factor for central nervous system (CNS) drug development. Although many model......

Trelagliptin Mitigates Macrophage Infiltration by Preventing the Breakdown of the Blood-Brain Barrier in the Brain of Middle Cerebral Artery Occlusion Mice

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (4)

Stroke is a significant cardiovascular disease that influences the health of human beings all over the world, especially the elderly population. It is......

Binimetinib Is a Potent Reversible and Time-Dependent Inhibitor of Cytochrome P450 1A2

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (4)

Binimetinib is a selective MEK1/2 inhibitor, which is indicative of melanoma. We aimed to investigate the inhibitory effect of binimetinib on cytochro......

Diclofenac Sodium Triggers p53-Dependent Apoptosis in Human Corneal Epithelial Cells via ROS-Mediated Crosstalk

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (1)

Diclofenac sodium (DFS), a nonsteroidal anti-inflammatory drug, is frequently used in ophthalmology, but it causes negative effects on corneas. The me......

Structure-Activity Relationship Investigation on Reaction Mechanism between Chlorinated Quinoid Carcinogens and Clinically-Used Aldoxime Nerve-Agent Antidote under Physiological Condition

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (4)

Pyridinium aldoximes are best-known therapeutic antidotes used for clinical treatment of poisonings by organophosphorus nerve-agents and pesticides. R......

Impact of Metal-Organic Frameworks on Protein Expression

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (6)

The influence of excessive metal-organic frameworks (MOFs) on the translation process was investigated in this study. Different concentrations and siz......

Myeloperoxidase Targets Apolipoprotein A-I for Site-Specific Tyrosine Chlorination in Atherosclerotic Lesions and Generates Dysfunctional High-Density Lipoprotein

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (6)

We previously demonstrated that apolipoprotein A-I (apoA-I), the major protein component of high-density lipoprotein (HDL), is an important target for......

Quantitation of Protein Adducts of Aristolochic Acid I by Liquid Chromatography-Tandem Mass Spectrometry: A Novel Method for Biomonitoring Aristolochic Acid Exposure

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (1)

Emerging evidence suggests that chronic exposure to aristolochic acids (AAs) is one of the etiological pathways leading to chronic kidney disease (CKD......

Integrated Proteomics and Metabolomics Assessment Indicated Metabolic Alterations in Hypothalamus of Mice Exposed to Triclosan

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (5)

Triclosan (TCS) is a ubiquitous antimicrobial used in many daily consumer products. It has been reported to induce endocrine disrupting effects at low......

Perfluorotridecanoic Acid Inhibits Leydig Cell Maturation in Male Rats in Late Puberty via Changing Testicular Lipid Component

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (6)

Perfluorotridecanoic acid (PFTrDA) is a long-chain (C13) perfluoroalkyl carboxylic acid. Here, we report the influence of PFTrDA exposure on the matur......

Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (7)

Cisplatin is a chemotherapeutic agent widely employed in the treatment of various solid tumors. However, its use is often restricted by acute kidney i......

Metabolic Activation and Cytotoxicity of Labetalol Hydrochloride Mediated by Sulfotransferases

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (6)

Labetalol hydrochloride (LHCl), an alpha- and beta-adrenoreceptor blocker, is widely used for the treatment of hypertension as well as angina pectoris......

In Silico Prediction of CYP2C8 Inhibition with Machine-Learning Methods

期刊: CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 24 (8)

Cytochrome P450 2C8 (CYP2C8) is a major drug-metabolizing enzyme in humans and is responsible for the metabolism of similar to 5% drugs in clinical us......

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