期刊： MOLECULAR CELL, 2022; 82 (23)
CRISPR-Cas are prokaryotic adaptive immune systems. Cas nucleases generally use CRISPR-derived RNA guides to specifically bind and cleave DNA or RNA t......
期刊： MOLECULAR CELL, 2022; 82 (24)
Maintenance of energy level to drive movements and material exchange with the environment is a basic prin-ciple of life. AMP-activated protein kinase ......
期刊： MOLECULAR CELL, 2022; 82 (24)
POLQ is a key effector of DSB repair by microhomology-mediated end-joining (MMEJ) and is overex-pressed in many cancers. POLQ inhibitors confer synthe......
期刊： MOLECULAR CELL, 2022; 82 (23)
Not only does Marseillevirus bear the name of the city where it was identified, it also encompasses its values and what makes Marseille a wonderful ci......
期刊： MOLECULAR CELL, 2022; 82 (23)
Transcriptional control is a highly dynamic process that changes rapidly in response to various cellular and extracellular cues, making it difficult t......
期刊： MOLECULAR CELL, 2022; 82 (24)
To explore genome organization and function in the HIV-infected brain, we applied single-nuclei transcrip-tomics, cell-type-specific chromosomal confo......
期刊： MOLECULAR CELL, 2022; 82 (23)
Gene expression heterogeneity underlies cell states and contributes to developmental robustness. While heterogeneity can arise from stochastic transcr......
期刊： MOLECULAR CELL, 2022; 82 (23)
In this issue, Liu et al. present an in-depth study aiming to unravel the structural, biochemical, and physiological aspects of how type III-E CRISPR-......
期刊： MOLECULAR CELL, 2022; 82 (24)
Second-messenger-mediated signaling by cyclic oligonucleotides (cOs) composed of distinct base, ring size, and 3'-5'/2'-5' linkage combinations consti......
期刊： MOLECULAR CELL, 2022; 82 (24)
Cell lineage specification is accomplished by a concerted action of chromatin remodeling and tissue -specific transcription factors. However, the mech......
期刊： MOLECULAR CELL, 2022; 82 (24)
PALI1 is a newly identified accessory protein of the Polycomb repressive complex 2 (PRC2) that catalyzes H3K27 methylation. However, the roles of PALI......
期刊： MOLECULAR CELL, 2022; 82 (24)
Long introns with short exons in vertebrate genes are thought to require spliceosome assembly across exons (exon definition), rather than introns, the......
期刊： MOLECULAR CELL, 2022; 82 (23)
Wu et al.1 characterize Cas12m, a compact Cas protein that silences transcription without cleaving DNA and is a prototype protein of the novel CRISPR-......
期刊： MOLECULAR CELL, 2022; 82 (23)
Bacteria have diverse defenses against phages. In response, jumbo phages evade multiple DNA-targeting defenses by protecting their DNA inside a nucleu......
期刊： MOLECULAR CELL, 2022; 82 (23)
The two doublet histones of Marseillevirus are distantly relatedto the foureukaryotic core histones andwrap121 base pairs of DNA to form remarkably si......
