L858R/T790M Discovery of highly potent and selective CRBN-recruiting EGFR(L858R/T790M )degraders in vivo

Zhang, WJ; Li, PY; Sun, SY; Jia, CK; Yang, N; Zhuang, XM; Zheng, ZB; Li, S

Zheng, ZB (通讯作者)，Beijing Inst Pharmacol & Toxicol, Lab Comp Aided Drug Design & Discovery, Beijing 100850, Peoples R China.;Zhuang, XM (通讯作者)，Beijing Inst Pharmacol & Toxicol, Key Lab Drug Metab & Pharmacokinet, Beijing 100850, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022; 238 ():

Abstract

Currently, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are widely used in the treatment of non-small cell lung cancer (NSC......

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