ACC 2022：五场全新揭晓的临床试验，23项研究的全新成果，三场特色临床研究

第71届美国心脏病学会年度科学会议（ACC 2022）将于2022年4月2-4日在美国华盛顿以线上线下相结合的方式举行。为期三天的会议设置了五场最新揭晓的临床试验（Late-Breaking Clinical Trials，LBCTs）专场，将公布23项研究的最新成果；三场特色临床研究（Featured Clinical Research，FCR）专场，将重点介绍15项研究的最新成果；两场LBCT深度探讨专题，聆听顶级专家讨论和辩论最新研究，具体都有哪些值得期待的研究，我们先睹为快吧！

Late-Breaking Clinical Trials

ACC 2022 ACC/JACC  LBCTs

Saturday, April 2  9:30 – 10:30 a.m. ET

VALOR-HCM: Mavacamten as An Alternative to Surgical Septal Myectomy or Alcohol Ablation in Patients With Severely Symptomatic Obstructive Hypertrophic Cardiomyopathy
VALOR-HCM研究：严重症状性梗阻性肥厚性心肌病患者应用mavacamten作为外科室间隔部分切除术和酒精室间隔消融的替代方案

SODIUM-HF: Study of Dietary Intervention Under 100 Mmol in Heart Failure
SODIUM-HF研究：100 mmol以下心力衰竭的饮食干预研究

The POISE-3 Trial: Efficacy and Safety of Tranexamic Acid in Patients Undergoing Noncardiac Surgery
POISE-3研究：氨甲环酸在非心脏手术患者中的疗效和安全性

CHAP Trial: Antihypertensive Therapy For Mild Chronic Hypertension Improves Pregnancy Outcomes: A Pragmatic Multicenter RCT
CHAP研究：轻度慢性高血压的降压治疗可改善妊娠结局的实用多中心随机对照试验

ACC/JAMA  LBCTs

Sunday, April 3  8 – 9:15 a.m. ET

MITIGATE: A Pragmatic Randomized Trial of Icosapent Ethyl for High Cardiovascular Risk Adults in an Era of Coronavirus Disease 2019
MITIGATE研究：在COVID-19大流行期间，二十碳五烯酸乙酯用于心血管高危成年人的实用随机试验

TRANSLATE-TIMI 70: Effect of Vupanorsen on Non-high-density Lipoprotein Cholesterol Levels In Statin-treated Patients With Elevated Cholesterol
TRANSLATE-TIMI 70研究：Vupanorsen注射液对他汀类药物治疗的胆固醇升高患者非高密度脂蛋白胆固醇水平的影响

PACMAN AMI: Effects of Alirocumab on Coronary Atherosclerosis Assessed by Serial Multimodality Intracoronary Imaging in Patients With Acute Myocardial Infarction: A Double-blind, Placebo-controlled, Randomized Trial
PACMAN AMI研究：一项双盲、安慰剂、随机对照试验：一系列冠状动脉多模态成像评估阿利西尤单抗对急性心肌梗死患者冠状动脉粥样硬化的影响

APOLLO Trial: Magnitude and Duration of Effects of a Short-interfering RNA Targeting Lipoprotein(a): A Placebo-controlled Double-blind Dose-ranging Trial
APOLLO研究：一项安慰剂、双盲、剂量范围试验：小干扰 RNA药物靶向治疗脂蛋白（a）的疗效幅度和持续时间

SuperWIN: A Multisite, Randomized, Controlled Trial of a Supermarket and Web-based Intervention Targeting Nutrition For Cardiovascular Risk Reduction
SuperWIN研究：一项针对超市和网络干预的多地点、随机、对照试验：营养水平对降低心血管风险的影响

ACC/NEJM  LBCTs

Sunday, April 3  9:45 – 11 a.m. ET

IVVE: Randomized Controlled Trial of Influenza Vaccine in Patients With Heart Failure to Reduce Adverse Vascular Events
IVVE研究：流感疫苗在心力衰竭患者中减少不良血管事件的随机对照试验

METEORIC-HF: The Effect of Omecamtiv Mecarbil on Exercise Tolerance in Patients With Chronic Heart Failure and Reduced Ejection Fraction
METEORIC-H研究：Omecamtiv-Mecarbil对慢性射血分数降低的心力衰竭患者运动耐量的影响

PROMPT-HF: A Cluster-Randomized PRagmatic Trial Aimed at ImprOving Use of Guideline Directed Medical Therapy in OutPatienTs With Heart Failure
PROMPT-HF研究：一项旨在改善门诊心力衰竭患者对指南指导的药物治疗使用的实用集群随机试验

DIAMOND Trial: Patiromer for the Management of Hyperkalemia in Subjects Receiving Renin-angiotensin-aldosterone System Inhibitor Medications For Heart Failure With Reduced Ejection Fraction
DIAMOND 研究：Patiromer在接受肾素-血管紧张素-醛固酮系统抑制剂治疗的射血分数降低的心力衰竭患者高钾血症治疗中的应用

Updated Cumulative Results of Treatment With Mavacamten From the EXPLORER-LTE Cohort of the MAVA-LTE Study in Patients With Obstructive Hypertrophic Cardiomyopathy
梗阻性肥厚性心肌病患者 MAVA-LTE 研究的 EXPLORER-LTE 队列中Mavacamten 治疗的累积结果的更新

LBCT IV

Monday, April 4  8:30 – 9:45 a.m. ET

The PROTECT Trial: Very Mild Perioperative Hypothermia Versus Aggressive Warming and Myocardial Injury After Non-cardiac Surgery
PROTECT试验：非心脏手术后极轻微的围手术期低温 vs. 剧烈升温的心肌损伤

POISE-3: The Effects of a Hypotension-avoidance Strategy Versus a Hypertension-avoidance Strategy In Patients Undergoing Noncardiac Surgery
POISE-3研究：在接受非心脏手术的患者中，避免低血压策略 vs. 避免高血压策略的效果比较

One-year Results of the Clasp TR Study: Transcatheter Treatment of Tricuspid Regurgitation
Clasp TR 研究的一年结果：三尖瓣反流的经导管治疗

Insights From the Corevalve US Pivotal and SURTAVI Trials: Five-year Incidence, Timing and Predictors of Hemodynamic Valve Deterioration of Transcatheter and Surgical Aortic Bioprostheses
Corevalve US Pivotal和 SURTAVI 试验的见解：经导管或外科主动脉瓣置换的心脏瓣膜血流动力学恶化的五年发病率、时间和预测因素

A Randomized ADAPT-TAVR Trial: Edoxaban Versus Dual Antiplatelet Therapy For Valve Thrombosis and Cerebral Thromboembolism After Transcatheter Aortic-valve Replacement
ADAPT-TAVR随机试验：TAVR后应用艾多沙班 vs. 双联抗血小板治疗瓣膜血栓和脑血栓栓塞的比较

LBCTs V

Monday, April 4  11 a.m. – 12:15 p.m. ET

GHATI: Improving STEMI Management Internationally: Two-year Report of 4,015 Patients Enrolled in the American College of Cardiology - Global Heart Attack Treatment Initiative
GHATI研究：改善STEMI的国际管理：美国心脏病学院-全球心脏病发作治疗倡议中4015例入选患者的两年报告

The FLAVOUR Randomized Clinical Trial: Comparison of Fractional Flow Reserve-guided and Intravascular Ultrasound-guided Percutaneous Coronary Intervention in Intermediate Coronary Artery Stenosis
FLAVOUR随机临床试验：FFR引导与IVUS引导下PCI治疗的冠状动脉狭窄的比较

GIPS-IV: The Groningen Intervention Study For the Preservation of Cardiac Function With Sodium Thiosulfate After St-segment Elevation Myocardial Infarction
GIPS-IV研究：硫代硫酸钠保护ST段抬高型心肌梗死后心功能的Groningen干预研究

BIO|GUARD-MI: The Clinical Effect of Arrhythmia Monitoring After Myocardial Infarction
BIO | GUARD-MI研究：心肌梗死后心律失常监测的临床效果

Featured Clinical Research

ACC 2022 FCR I

Saturday, April 2  11 a.m. – 12:15 p.m. ET

SCORED Trial: Sotagliflozin Significantly Reduces Cardiovascular Death, Myocardial Infarction, and Stroke in the Scored Trial
SCORED试验：索格列净显著降低心血管死亡、心肌梗死和卒中风险

Bentracimab Immediately and Significantly Reverses the Antiplatelet Effects of Ticagrelor in Older People
Bentracimab可迅速显著逆转替格瑞洛在老年人群中的抗血小板作用

COMPLETE: Effects of Complete Revascularization on Angina-related Quality of Life in Patients With St-segment Elevation Myocardial Infarction
COMPLETE研究：完全血运重建对ST段抬高型心肌梗死患者心绞痛相关生活质量的影响

The FAME 3 Trial: Quality of Life After Fractional Flow Reserve-guided Stenting Compared With Coronary Bypass Surgery
FAME 3研究：FFR指导下支架置入术与冠状动脉搭桥手术后的生活质量比较

Results of the EDIT-CMD Randomized Clinical Trial: Efficacy of Diltiazem to Improve Coronary Vasomotor Dysfunction in Angina and Nonobstructive Coronary Arteries
EDIT-CMD随机临床试验的结果：地尔硫卓改善心绞痛和非阻塞性冠状动脉血管舒缩功能障碍的疗效

FCR II

Sunday, April 3  12:15 – 1:30 p.m. ET

PACIFIC AF: Multicenter, Randomized, Active Comparator-controlled, Double-blind, Double-dummy, Parallel Group, Dose-finding Phase 2 Study Comparing the Safety of the Oral FXIa Inhibitor Asundexian With Apixaban in Patients With Atrial Fibrillation
PACIFIC AF研究：一项多中心、随机双盲、平行对照2期试验：比较口服FXIa抑制剂Asundexian与阿哌沙班在房颤患者中的安全性

Residual Leaks Post Left Atrial Appendage Occlusion
左心耳封堵后的残余漏

A Report From the mAFA-II Trial Long-term Extension Cohort: Consumer-led Screening For Atrial Fibrillation
mAFA-II试验长期扩展队列报告：消费者主导的心房颤动筛查

Results From the PARTITA Trial: Catheter Ablation of Ventricular Tachycardia After the First Implantable Cardioverter Shock
PARTITA试验结果：首次植入式心脏复律电击后，进行室性心动过速经导管射频消融治疗

Low Rates of Guideline Directed Care Associated With Higher Mortality in Patients With Infections of Pacemakers and Implantable Cardioverter Defibrillators
心脏起搏器和植入式心脏复律除颤器术后感染患者的低指南依从性治疗与高死亡率相关

FCR III

Monday, April 4  12:45 – 2 p.m. ET

3-year Efficacy Outcomes From the Spyral Htn-on Med Pilot Study: Long Term Effect of Renal Denervation On Blood Pressure Reduction in Patients on Antihypertension Medications
Spyral Htn-on Med Pilot研究的3 年疗效结果：肾脏去神经支配疗法对服用降压药物患者血压降低的长期影响

Fidelity Analyses: Finerenone and Cardiorenal Outcomes by History of Cardiovascular Disease in Patients With Type 2 Diabetes
Fidelity分析：Finerenone在伴有心血管疾病病史的2型糖尿病患者中的心肾结局

Secondary Analysis of the CANTOS Trial: Differential Impact of Residual Inflammatory Risk and Residual Cholesterol Risk Among Atherosclerosis Patients With and Without Chronic Kidney Disease
CANTOS试验的二次分析：残余炎症风险和残余胆固醇风险对伴和不伴有慢性肾脏疾病的动脉粥样硬化患者的不同影响

Trends and Final Results of the North American Covid-19 Myocardial Infarction (NACMI) Registry
北美COVID-19心肌梗死登记研究（NACMI）的趋势和最终结果

Results From the EMPULSE Trial: Effects of Empagliflozin on Symptoms, Physical Limitations and Quality of Life in Patients Hospitalized For Acute Heart Failure
EMPULSE试验结果：恩格列净对急性心力衰竭住院患者症状、体力活动限制和生活质量的影响

原始出处：

Late-Breakers (acc.org)