Environ Pollut:对疑似脓毒症的急诊患者:微生物学结果和抗生素过度使用

2017-06-28 MedSci MedSci原创

本研究旨在于研究急诊科(ED)住院病人中脓毒症患者的细菌感染和抗生素使用情况。

本研究旨在于研究急诊科(ED)住院病人中脓毒症患者的细菌感染和抗生素使用情况。

为观察性回顾性队列研究。纳入研究对象为从2011年1月1日到6月1日,在大型教学医院的急诊室就诊年龄在18岁以上的成人,纳入患者必须符合两个以上的SIRS标准,疑似脓毒症的患者也纳入研究对象。

实验结果显示,疑似脓毒症(2008定义)的患者中只有71%被确诊,确认后立即给予抗生素治疗。大多数患者(58%)引起了全身炎症反应综合征(SIRS),这些患者中无器官功能不全、低血压或低灌注的表现。尽管经过严格的诊断后,纳入研究的患者中有29%并未检测到细菌感染,仍然对本组受试者进行了为期7天的抗生素治疗(IQR 4-10)。

在此研究中,使用SIRS标准和对临床怀疑的脓毒症的患者进行检测,经排除其中有71%确诊患有脓毒症。相当一部分没有细菌感染证据的患者也长期给予抗生素治疗。这项研究说明了正确识别细菌感染性疾病和脓毒症的困难,并表明这可能是导致过度使用抗生素的原因。

原始出处:

Kemény 1, Csek K2, et al. Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model. Environ Pollut. 2017 Jun 22. pii: S0269-7491(16)31444-0. doi: 10.1016/j.envpol.2017.04.098.

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