Heart:自身免疫性疾病增加心血管疾病和死亡风险

2017-08-30 MedSci MedSci原创

来自医院del Mar Medical Research Institute(IMIM)和IDIAP Jordi Gol的研究人员刚刚发表了一篇文章,表明自身免疫性疾病会显着增加心血管疾病的风险和总体死亡率。这在患有风湿性关节炎或系统性红斑狼疮的人身上尤其明显。此外,还发现炎症性肠病,如克罗恩病或溃疡性结肠炎,中风和死亡的风险也会增加。这篇文章发表在本月的《Heart》杂志上。这项研究为期6年,对


来自医院del Mar Medical Research Institute(IMIM)和IDIAP Jordi Gol的研究人员刚刚发表了一篇文章,表明自身免疫性疾病会显著增加心血管疾病的风险和总体死亡率。这在患有风湿性关节炎或系统性红斑狼疮的人身上尤其明显。此外,还发现炎症性肠病,如克罗恩病溃疡性结肠炎,中风和死亡的风险也会增加。这篇文章发表在本月的《Heart》杂志上。

这项研究为期6年,对近100万年龄在35到85岁之间的无心血管疾病史的人群进行了跟踪。大样本容量可以估算出患有自身免疫性疾病的人的心血管事件发生率和死亡率。这些疾病中某些疾病出现的频率较高,所以它们的影响是相当显着的。据估计,在西班牙,风湿性关节炎影响着15万到20万人,大约10万人患有克罗恩病溃疡性结肠炎

"我们想确定患有自身免疫性炎症疾病,包括克罗恩病和溃疡性结肠炎,类风湿性关节炎,系统性红斑狼疮或强直性脊柱炎等疾病的患者同时患冠心病,中风或总死亡率的风险,以及 确定每个病理学的发生率",IMIM心血管疾病流行病学研究组和文章主要作者MaríaGrau研究员解释说。
研究结果显示,如狼疮和风湿性关节炎等结缔组织的系统性疾病,与心血管疾病和整体死亡风险的相关性更高,其次是炎症性肠病,如克罗恩病和溃疡性结肠炎,这些疾病增加了中风和死亡的风险。虽然先前的研究已经显示了慢性自身免疫性炎症疾病与心血管风险之间的关系,但样本的大尺寸和本研究的设计使结果更具一般性。

玛丽亚·格劳解释说:"人们认为,风湿性关节炎和红斑狼疮的心血管疾病和死亡率的增加是由于炎症、代谢因素、治疗和疾病相关因素的相互作用造成的。" 她补充说:"因此,开发新的预测心血管事件的工具,其中包括自身免疫性炎症疾病活动的生物标记物,有助于降低这些事件的发生率。"。

预防心血管疾病是公共卫生议程的一项关键重点,因为它是发达国家死亡的主要原因,也是发展中国家死亡率增加的主要原因。心血管疾病的共同基础是动脉粥样硬化,这是一种贯穿人一生的炎性退行性过程。

自身免疫性疾病影响到人们生活中最具生命力的阶段,并且非常严重。早期发现是至关重要的,因为在疾病开始的一段时间里,对其他器官的永久性损伤仍然可以避免。更好地了解这些疾病和心血管疾病发病率之间的关系,可能有助于及早评估和管理危险因素,改善这些疾病患者的长期预后。


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    2017-09-15 周周人

    学习.一

    0

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    2017-09-02 周周人

    学习.

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    2017-09-01 zhaojie88
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    2017-09-01 slcumt
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    2017-08-31 130****4638

    学习了谢谢分享

    0

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    2017-08-30 1e0f8808m18(暂无匿称)

    自身免疫疾病严重危害人类健康.

    0

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学术界和产业界的研发人员掀起了调节性T细胞的研发热潮,以期通过免疫抑制细胞抑制自身免疫性疾病。7月24日,位于美国印第安纳州印第安纳波利斯市的礼来公司宣布将支付4亿美元来支持开发一种刺激调节性T细胞的药物,该药物在3月份进入临床试验阶段。1月份,新基生物医药公司(Celgene)宣布计划以3亿美元的价格收购一家做类似药物的公司。T细胞通常被认为是免疫系统对抗外来入侵者的关键步兵。但T细胞种类繁多,

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Guillain Barré综合症(GBS)是一种罕见的自身免疫性疾病——攻击自身神经系统导致肌肉无力,严重情况下课导致瘫痪。目前关GBS的病因尚未清楚,来自梅奥诊所的一项新的研究表明,外科手术或可促进其发生,该研究结果已发表于Neurology Clinical Practice。美国神经病学学会(AAN)指出手术或可偶然引发GBS的发生。然而,新的研究表明近期行手术治疗的患者中,GBS的发病率

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这些数据表明人类自身免疫性疾病的特征在于BTK活性增强,BTK活性增强不仅与自身抗体形成并且与T细胞活性有关。

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近期,美国内分泌学会主办的学术期刊Journal of Clinical Endocrinology and Metabolism 在线发表了中国科学院上海巴斯德研究所李斌课题组与中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所范先群课题组的合作研究成果,揭示了炎性因子IL-17A调控甲状腺相关眼病(Thyroid-associated ophthalmopathy,TAO)发生发展