Nature Communications:胎盘能够保护胎儿不受来自母体的新冠病毒感染

2022-01-20 “生物世界”公众号 “生物世界”公众号

虽然感染新冠病毒的大部分孕妇都无症状或症状较轻,但有研究显示,孕妇出现重症的风险可能更高。然而,我们尚不清楚无症状或轻症感染会如何影响母胎交叉区域和胎儿健康。

虽然感染新冠病毒的大部分孕妇都无症状症状较轻,但有研究显示,孕妇出现重症的风险可能更高。然而,我们尚不清楚无症状或轻症感染会如何影响母胎交叉区域和胎儿健康

2022年1月18日,美国国立卫生研究院(NIH)的研究人员在 Nature Communications 发表了题为:Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2 的研究论文。

该研究研究分析了孕期新冠病毒(SARS-CoV-2)检测呈阳性的12名女性,分析显示,孕期的新冠病毒暴露会导致一种母体和胎儿细胞共同参与的胎盘炎症反应,但不会感染胎盘组织

为了充分了解孕期感染新冠病毒的影响,研究团队入组了12名怀孕且新冠病毒检测呈阳性的女性以及11名健康的对照。在检测呈阳性的女性中,8人为无症状感染,1人轻症,3人为需要吸氧的重症。

研究团队在母体病毒暴露后的胎盘以及母亲和胎儿的血液中均观察到一种很特别的促炎性免疫应答。他们发现,虽然针对新冠病毒的母源抗体会通过胎盘传给胎儿,但胎盘中既没发现胎儿抗体也没发现新冠病毒。作者认为,这说明胎盘能保护胎儿不受感染。

研究团队指出,这项研究结果增进了我们对感染新冠病毒后母胎免疫应答的理解,并提示从母体到胎儿的垂直传播可能极为罕见。不过,他们也提醒该结论应当谨慎解读,因为研究中感染新冠重症的孕妇人数很有限。

原始出处:

Garcia-Flores, V., Romero, R., Xu, Y. et al. Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2. Nat Commun 13, 320 (2022). https://doi.org/10.1038/s41467-021-27745-z.

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    2022-09-18 liuli5079
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    2022-04-07 liye789132251
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