Eur Urol:将勃起功能恢复的年龄差异考虑入根治性前列腺切除术的利弊。

2017-08-31 fengxiangxin MedSci原创

尽管主动监测越来越多地应用于低危前列腺癌患者的管理中,但许多符合条件的患者仍然接受了手术治疗。患者考虑手术而不是主动监视的一个原因是存在这样一个论点:术后勃起功能的恢复可能性是年龄依赖性的,也就是说,延迟手术的患者可能失去手术后恢复勃起功能的机会。

尽管主动监测越来越多地应用于低危前列腺癌患者的管理中,但许多符合条件的患者仍然接受了手术治疗。患者考虑手术而不是主动监视的一个原因是存在这样一个论点:术后勃起功能的恢复可能性是年龄依赖性的,也就是说,延迟手术的患者可能失去手术后恢复勃起功能的机会。

为了比较选择即时手术的患者在术后10年中勃起功能的与主动监测患者的差异,研究者使用了来自第三转诊中心接受了根治性前列腺切除术的1103名男性患者的数据。

患者将术前术后完成国际勃起功能指数(IIEF-5)评分作为常规临床护理工作的一部分。研究者绘制了术前IIEF-6评分的年龄相关曲线以评估勃起功能由于年龄老化的自然下降率。手术后2年内的勃起功能评分被用来评估手术后的恢复情况。

患者进行即时手术的年龄每增加一岁导致了IIEF评分减少0.27。除了IIEF评分随年龄的增加减少之外,术前到术后12个月内勃起功能恢复的数量也随之减少了(-0.16IIF分/年,95%置信区间:0.27,0.05,P = 0.006)。然而,与立即手术相比,即使假定所有的患者在主动监测的5年内接受了治疗,延迟前列腺癌根治术患者的平均IIEF-6评分在超过一个10年的时间段内却增加了(P = 0.001)。

年轻男性在勃起功能恢复方面的微小差异会被术后较长时间的功能下降所抵消。因此,年轻男性术后更好的勃起恢复不应成为适合主动监测的患者选择即时手术的考虑因素。

原始出处:


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    2018-05-25 lujian
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    2017-11-27 zhaojie88
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    2017-09-02 jeanqiuqiu
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    2017-09-02 mnda

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