Neurology:耳石症频发,多补补维生素D和钙试试!

2021-02-27 MedSci原创 MedSci原创

良性阵发性位置性眩晕(BPPV)的特点是由头部相对于重力的位置变化引起的短暂眩晕发作,也叫耳石症。虽然BPPV是一种良性疾病,但近86%的BPPV患者因眩晕、呕吐等症状严重影响了其日常生活、工作和学习

良性阵发性位置性眩晕(BPPV)的特点是由头部相对于重力的位置变化引起的短暂眩晕发作,也叫耳石症。虽然BPPV是一种良性疾病,但近86%的BPPV患者因眩晕、呕吐等症状严重影响了其日常生活、工作和学习。有研究发现,BPPV患者维生素D缺乏/不足和骨质密度下降的发生率更高,但是缺乏前瞻性研究来证实。近日,一项平行、多中心、随机对照试验评估了维生素D和钙补充剂对预防BPPV复发的影响,发现维生素D和钙补充剂可降低BPPV的复发,研究结果已在线发表于Neurology。

研究人员在2013年12月至2017年5月期间,在8家医院纳入确诊为BPPV的患者,手法成功治疗后随机分配到干预组(n = 518)或观察组(n = 532)。主要结果是年复发率(ARR)。干预组患者在血清维生素D水平低于20 ng/mL时,曾服用维生素D 400 IU和500 mg碳酸钙,每天两次,持续1年。观察组患者被安排随访,没有进一步评估维生素D或补充维生素D。

 

结果显示,干预组ARR的复发率降低(0.83[95%CI,0.74-0.92]vs 1.10[95%CI,1.00-1.19]每1人年),发生率比为0.76(95%CI,0.66-0.87,P<0.001),绝对率比为-0.27(-0.40~-0.14)。需要治疗的人数为3.70(95% CI,2.50~7.14)。干预组复发患者的比例也低于观察组(37.8 vs 46.7%,p = 0.005)。

综上所述,该研究结果表明,对于BPPV频繁发作的患者可考虑补充维生素D和钙,尤其是血清维生素D较低时。

 

原始出处:

 

Seong-Hae Jeong, Ji-Soo Kim, et al., Prevention of benign paroxysmal positional vertigo with vitamin D supplementation: A randomized trial. Neurology. 2020 Sep 1;95(9):e1117-e1125. doi: 10.1212/WNL.0000000000010343.

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    2022-01-15 yinhl1978
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    2021-03-01 科研科研科研

    补维生素D和钙可预防耳石症频发

    0

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    2021-02-27 jyzxjiangqin

    好文章!

    0

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