Stroke:高血压患者服用非甾体抗炎药(NSAIDs)增加卒中风险

2015-05-05 徐媛媛译 MedSci原创

已经有研究调查了脑血管事件发生风险与高危患者使用非甾体类抗炎药(NSAIDs)之间的关系,但研究很有限。该研究调查了使用选择性和非选择性非甾体类抗炎药短期内(30天内)对高血压患者的缺血性和出血性卒中风险的影响。 使用台湾国家健康保险研究数据库进行了一项病例交叉研究。该研究确定了来自2010年的1653患有卒中的高血压患者。调整了潜在混杂因素后利用条件逻辑评估了使用NSAIDs对卒中的影响。

已经有研究调查了脑血管事件发生风险与高危患者使用非甾体类抗炎药(NSAIDs)之间的关系,但研究很有限。该研究调查了使用选择性和非选择性非甾体类抗炎药短期内(30天内)对高血压患者的缺血性和出血性卒中风险的影响。

使用台湾国家健康保险研究数据库进行了一项病例交叉研究。该研究确定了来自2010年的1653患有卒中的高血压患者。调整了潜在混杂因素后利用条件逻辑评估了使用NSAIDs对卒中的影响。

研究结果表明,在卒中前30天内服用NSAIDs缺血性卒中风险会增加1.57倍,但对出血性卒中无影响(校正后比值比,1.57;95% CI,缺血性卒中1.26–1.97;校正后比值比,1.38;95% CI,出血性卒中0.79–2.40)。当把NSAIDs分到选择性和非选择性小组时,在非选择性NSAIDs使用组的缺血性卒中风险明显增加(校正后比值比,1.55;95% CI,1.24–1.94),而出血性卒中风险无变化(校正后比值比1.56;95% CI,0.90–2.73)。

结果表明,在高血压患者中使用NSAIDs增加缺血性卒中风险。严密监测初始NSAIDs治疗瞬态效应将非常重要,特别对于高血压患者来讲。

原始出处

Shao-Yuan Chuang, PhD, Yunxian Yu, MD, PhD, Wayne Huey-Herng Sheu, MD, PhD, Yu-Ting Tsai, MS, Xin Liu, MD, PhD, Chao A. Hsiung, PhD and Hui-Ju Tsai, MPH.Association of Short-Term Use of Nonsteroidal Anti-Inflammatory Drugs With Stroke in Patients With Hypertension. stroke. March 3, 2015

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    2016-04-17 wjywjy
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    2015-06-09 d830372
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  5. 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  6. 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  7. 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topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Thu May 07 04:49:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22702, encodeId=3a1022e026b, content=找原文看看,暂时不能理解, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e2598150, createdName=lcrzl, createdTime=Wed May 06 06:20:00 CST 2015, time=2015-05-06, status=1, ipAttribution=)]
    2015-05-07 cooco
  8. 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topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Thu May 07 04:49:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22702, encodeId=3a1022e026b, content=找原文看看,暂时不能理解, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e2598150, createdName=lcrzl, createdTime=Wed May 06 06:20:00 CST 2015, time=2015-05-06, status=1, ipAttribution=)]
    2015-05-07 amyloid
  9. [GetPortalCommentsPageByObjectIdResponse(id=2033820, encodeId=49062033820e4, content=<a href='/topic/show?id=852b216824' target=_blank style='color:#2F92EE;'>#AID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2168, encryptionId=852b216824, topicName=AID)], attachment=null, authenticateStatus=null, createdAvatar=/img/user_icon.png, createdBy=1072181, createdName=wjywjy, createdTime=Sun Apr 17 19:49:00 CST 2016, time=2016-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793573, encodeId=30de1e9357395, content=<a href='/topic/show?id=0a3c158509b' target=_blank style='color:#2F92EE;'>#SAID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15850, encryptionId=0a3c158509b, topicName=SAID)], attachment=null, authenticateStatus=null, createdAvatar=, 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  10. [GetPortalCommentsPageByObjectIdResponse(id=2033820, encodeId=49062033820e4, content=<a href='/topic/show?id=852b216824' target=_blank style='color:#2F92EE;'>#AID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2168, encryptionId=852b216824, topicName=AID)], attachment=null, authenticateStatus=null, createdAvatar=/img/user_icon.png, createdBy=1072181, createdName=wjywjy, createdTime=Sun Apr 17 19:49:00 CST 2016, time=2016-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793573, encodeId=30de1e9357395, content=<a href='/topic/show?id=0a3c158509b' target=_blank style='color:#2F92EE;'>#SAID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15850, encryptionId=0a3c158509b, topicName=SAID)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Thu May 07 04:49:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22702, encodeId=3a1022e026b, content=找原文看看,暂时不能理解, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e2598150, createdName=lcrzl, createdTime=Wed May 06 06:20:00 CST 2015, time=2015-05-06, status=1, ipAttribution=)]
    2015-05-06 lcrzl

    找原文看看,暂时不能理解

    0

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