Clin Infect Dis:新倡议能否改善金黄色葡萄球菌菌血症患者的治疗质量

2017-08-15 梁舒瑶 环球医学资讯

2017年4月,发表在《Clin Infect Dis》的一项由美国科学家进行的回顾性、单中心、准实验研究,考察了一项由药师主导的对抗菌药物管理干预的倡议能否改善金黄色葡萄球菌菌血症(SAB)患者的治疗质量。

2017年4月,发表在《Clin Infect Dis》的一项由美国科学家进行的回顾性、单中心、准实验研究,考察了一项由药师主导的对抗菌药物管理干预的倡议能否改善金黄色葡萄球菌菌血症(SAB)患者的治疗质量。

背景感染性疾病(ID)咨询和抗菌药物管理干预已经表现出,可改善SAB的管理。由于抗菌药物管理计划(ASP)工作负担继续增加,ASP必须要找到一条在将ASP效率最大化的同时优化患者结局的出路。本研究的目的为评估,通过药师主导的倡议将健康信息学融入SAB管理中的影响。

方法:这是一项SAB住院患者的回顾性、单中心、准实验研究。干预期,药师通过融入到电子病历记录中的患者评分工具对SAB患者进行提醒。药师使用评分工具和机构的循证实践指南来制定标准化的建议,从而促进SAB治疗质量测量的依从性,并鼓励ID咨询。首要结局为总体依从性以及个体治疗质量部分的依从性,同时也分析了次要结局。

结果:总计84例患者纳入研究,干预前组45例,干预组39例。作为整体,干预组的患者中,SAB管理的所有4个治疗质量部分都显着性更依从(68.9% vs 92.3%;P=0.008)。干预组的患者,ID咨询率出现了几乎20%的显着性改善(75.6% vs 94.9%;P=0.015)。组间菌血症病程、住院日、感染相关住院日、再入院率没有统计学显着性差异。干预前组的全因死亡率比干预组高6倍(15.6% vs 2.6%;P=0.063)。

结论:管理SAB患者的自动化药师主导的干预措施可显着性改善ID咨询、针对性抗菌治疗和所有SAB治疗质量测量的依从性。在美国的所有医院中,由于抗菌药物管理已经成为医疗的强制性措施,ASP将关注于寻找更有效、更具影响力的基于疾病状态的患者治疗的方法。研究提供了一个框架和数据,为使用该药师主导的倡议干预多数临床中重要的感染性疾病提供了支持。

原始出处:
Wenzler E, Wang F, Goff DA,et al. An Automated, Pharmacist-Driven Initiative Improves Quality of Care for Staphylococcus aureus Bacteremia.Clin Infect Dis. 2017 Apr 4. doi: 10.1093/cid/cix315. [Epub ahead of print]

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    2017-08-16 明天会更好!

    不错的文章,值得学习!

    0

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    2017-08-16 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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Crit Care Med:ICU中成人耐甲氧西林金黄色葡萄球菌预防的建议

ICU中的患者发生医疗相关感染(如耐甲氧西林的金黄色葡萄球菌)的风险较高。近期,一项发表在杂志Crit Care Med上的研究评估了耐甲氧西林金黄色葡萄球菌的预防策略的成本效益,并基于筛选实验提出了具体策略。此项研究从医院的角度,使用马尔可夫模型的成本效益分析,以确定通过降低耐甲氧西林金黄色葡萄球菌感染和改善质量调整生命年,耐甲氧西林金黄色葡萄球菌预防策略的实施成本是否合适。使用单变量和概率敏感

Sci Signal:首次揭示金黄色葡萄球菌耐受高盐浓度机制

在一项新的研究中,来自英国帝国理工学院的研究人员发现一种新的方法来攻击金黄色葡萄球菌。他们揭示出这种细菌如何调节它的盐水平。相关研究结果发表在2016年8月16日那期Science Signaling期刊上,论文标题为“The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in Staphylococcus a

JACS:上海科技大学季泉江组研发出“超级细菌”基因组编辑新技术

日前,国际期刊《Journal of the American Chemical Society》杂志上在线发表了上海科技大学物质学院(材料生物学研究部)季泉江助理教授课题组在人类致病菌金黄色葡萄球菌(包括其中的“超级细菌”)中首次建立起基于CRISPR/Cas9系统的、高效快速的基因组编辑方法。研究成果题为“Rapid and Efficient Genome Editing in Staphy

J Infect:类风湿性关节炎患者:金黄色葡萄球菌菌血症猛于虎

2017年6月,发表在《J Infect》的来自前瞻性INSTINCT队列的数据,揭示了类风湿性关节炎(RA)患者中,金黄色葡萄球菌菌血症(SAB)的情况。