DIABETOLOGIA:孕产妇妊娠期体重增加对儿童心脏代谢危险因素的影响

2018-11-30 MedSci MedSci原创

越来越多的证据表明妊娠期体重增加(GWG)对妊娠结局会产生一定的影响, 然而,目前尚未有关生命后期心脏代谢风险因素的数据。本研究旨在评估GWG与7岁后代心脏代谢风险之间的关系。 研究人员在香港中心参与了多中心高血糖和不良妊娠结局研究的随访,共纳入了905对母子。女性被分类为体重增加,处于,还是超出2009年医学院(IOM)指南三组。计算根据孕前BMI类别的标准化GWG以探讨任何相互

越来越多的证据表明妊娠期体重增加(GWG)对妊娠结局会产生一定的影响, 然而,目前尚未有关生命后期心脏代谢风险因素的数据。本研究旨在评估GWG7岁后代心脏代谢风险之间的关系。

研究人员在香港中心参与了多中心高血糖和不良妊娠结局研究的随访,共纳入了905对母子。女性被分类为体重增加,处于,还是超出2009年医学院(IOM指南三组。计算根据孕前BMI类别的标准化GWG以探讨任何相互关系。

结果显示,与孕前BMI,妊娠期高血糖症和其他混杂因素无关,体重增加超过IOM推荐标准的女性比怀孕期间体重增加处于范围内的女性,其后代体型更大,患肥胖症的几率也更高(所有性状的p值范围:4.6 ×10 -9  <  p  <0.0390)。与此同时,与建议范围内体重增加的患者(7.9 × 10−3 < p < 0.0477相比,体重增加低于建议范围内的女性后代患有高血压和胰岛素抵抗风险增加。在标准化GWG的分析中,确认了舒张压,胰岛素AUC,胰岛β细胞功能和胰岛素敏感指数的二次关系(1.4×10 -3  <  二次  <0.0282)。对当前BMI的进一步调整显著减弱了观察到的关联。

GWG过度和不足都会对儿童肥胖,高血压和胰岛素抵抗产生独立而显著的影响。研究结果支持这样一种观点,即宫内不良暴露与后代的持续心脏代谢风险有关。

原始出处:

Claudia H. T. Tam, Ronald C. W. Ma, The impact of maternal gestational weight gain on cardiometabolic risk factors in children

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    2018-12-04 orangesking

    0

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    2018-11-30 医者仁心5538

    学习了

    0

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