Circ Res:空气污染损伤血管内皮,引发心血管疾病

2016-10-29 MedSci MedSci原创

美国心脏病协会《循环研究》(Circ Res)杂志25日刊登的一项新研究说,空气污染能伤害健康年轻人的血管,这有助于解释为什么空气污染可能会引发心血管疾病。 由于受地理条件等影响,美国犹他州普罗沃市会周期性出现相对严重的空气污染,曾被评为美国空气污染最严重的十大城市之一。从2013年开始,研究人员连续3个冬季抽取普罗沃市72名健康成年人的血样进行评估,这些人都不吸烟,参加研究时的平均年龄



美国心脏病协会《循环研究》(Circ Res)杂志25日刊登的一项新研究说,空气污染能伤害健康年轻人的血管,这有助于解释为什么空气污染可能会引发心血管疾病。

由于受地理条件等影响,美国犹他州普罗沃市会周期性出现相对严重的空气污染,曾被评为美国空气污染最严重的十大城市之一。从2013年开始,研究人员连续3个冬季抽取普罗沃市72名健康成年人的血样进行评估,这些人都不吸烟,参加研究时的平均年龄为23岁。

血样分析结果显示,每当空气中直径小于2.5微米的细颗粒物(PM2.5)浓度上升时,这些年轻人血样中的心血管疾病标志物水平也会出现异常变化。例如,血样中显示血管细胞伤害与死亡情况的微粒数量显著增加,抑制血管生长与预示血管炎症的蛋白水平也同样增加。

参与研究的美国路易斯维尔大学教授阿鲁尼·巴特纳格尔说,这些发现表明空气污染引发高血压、心脏病及中风的情况可能比先前认为的更普遍,而且发生在比先前认为更早期的年龄阶段。

巴特纳格尔说:“虽然我们已经知道空气污染可能在高风险易感人群中引起心脏病发作或中风,但这项发现显示空气污染甚至也能影响看似健康的人群,这表明我们所有人都应关注空气污染,而不仅仅是病人或老年人。”

24日,欧洲研究人员在《欧洲心脏病学杂志》(Eur Heart J)上报告说,长期生活在空气污染严重城市中的人,患高血压的风险将显著升高。

原始出处:

Pope CA, Bhatnagar A, McCracken J, Abplanalp WT, Conklin DJ, O'Toole TE. Exposure to Fine Particulate Air Pollution Is Associated with Endothelial Injury and Systemic Inflammation. Circ Res. 2016 Oct 25. pii: CIRCRESAHA.116.309279.

Münzel T, Sørensen M, Gori T, Schmidt FP, Rao X, Brook J, Chen LC, Brook RD, Rajagopalan S. Environmental stressors and cardio-metabolic disease: part I-epidemiologic evidence supporting a role for noise and air pollution and effects of mitigation strategies. Eur Heart J. 2016 Jul 26. pii: ehw269. Review.

Münzel T, Sørensen M, Gori T, Schmidt FP, Rao X, Brook FR, Chen LC, Brook RD, Rajagopalan S. Environmental stressors and cardio-metabolic disease: part II-mechanistic insights. Eur Heart J. 2016 Jul 26. pii: ehw294. Review.

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ab71958514, createdName=四爷无名, createdTime=Sun Oct 30 23:41:52 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152175, encodeId=802c1521e52f, content=北京天津很差, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Oct 30 10:25:21 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152174, encodeId=256c1521e4cb, content=环境污染很重, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, 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2.5颗粒有毒有害分析 后来就被消声了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10071932021, createdName=少年尼采, createdTime=Sat Oct 29 13:22:36 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2016-10-30 四爷无名

    学习了,非常好的文章,很详细,很实用

    0

  5. 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2.5颗粒有毒有害分析 后来就被消声了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10071932021, createdName=少年尼采, createdTime=Sat Oct 29 13:22:36 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2016-10-30 doctorJiangchao

    北京天津很差

    0

  6. 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2.5颗粒有毒有害分析 后来就被消声了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10071932021, createdName=少年尼采, createdTime=Sat Oct 29 13:22:36 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2016-10-30 doctorJiangchao

    环境污染很重

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ab71958514, createdName=四爷无名, createdTime=Sun Oct 30 23:41:52 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152175, encodeId=802c1521e52f, content=北京天津很差, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Oct 30 10:25:21 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152174, encodeId=256c1521e4cb, content=环境污染很重, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Oct 30 10:24:51 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152173, encodeId=805c1521e30f, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Oct 30 10:24:33 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151989, encodeId=768d15198901, content=北京的霾为医学医院?增加了负担啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Sat Oct 29 15:41:35 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151957, encodeId=fd5115195e0b, content=治病,预防先行, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib1VDvmgcW1U7iatqib3zWp2hc0XDjkia6BWsQg86Bmjv2kgwZb11orQeIrV5czIiaOnmnrxyJiaMPrzzL6qibkLiazYX05/0, createdBy=07481682680, createdName=ellenli, createdTime=Sat Oct 29 13:38:21 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151948, encodeId=08af1519488c, content=复旦公共卫生学院做过上海 2.5颗粒有毒有害分析 后来就被消声了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10071932021, createdName=少年尼采, createdTime=Sat Oct 29 13:22:36 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2016-10-30 doctorJiangchao

    值得关注

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ab71958514, createdName=四爷无名, createdTime=Sun Oct 30 23:41:52 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152175, encodeId=802c1521e52f, content=北京天津很差, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Oct 30 10:25:21 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152174, encodeId=256c1521e4cb, content=环境污染很重, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, 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content=北京的霾为医学医院?增加了负担啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Sat Oct 29 15:41:35 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151957, encodeId=fd5115195e0b, content=治病,预防先行, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib1VDvmgcW1U7iatqib3zWp2hc0XDjkia6BWsQg86Bmjv2kgwZb11orQeIrV5czIiaOnmnrxyJiaMPrzzL6qibkLiazYX05/0, createdBy=07481682680, createdName=ellenli, createdTime=Sat Oct 29 13:38:21 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151948, encodeId=08af1519488c, content=复旦公共卫生学院做过上海 2.5颗粒有毒有害分析 后来就被消声了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10071932021, createdName=少年尼采, createdTime=Sat Oct 29 13:22:36 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2016-10-29 meiliwuxian

    北京的霾为医学医院?增加了负担啊

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Oct 30 10:24:51 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152173, encodeId=805c1521e30f, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Oct 30 10:24:33 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151989, encodeId=768d15198901, content=北京的霾为医学医院?增加了负担啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Sat Oct 29 15:41:35 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151957, encodeId=fd5115195e0b, content=治病,预防先行, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib1VDvmgcW1U7iatqib3zWp2hc0XDjkia6BWsQg86Bmjv2kgwZb11orQeIrV5czIiaOnmnrxyJiaMPrzzL6qibkLiazYX05/0, createdBy=07481682680, createdName=ellenli, createdTime=Sat Oct 29 13:38:21 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151948, encodeId=08af1519488c, content=复旦公共卫生学院做过上海 2.5颗粒有毒有害分析 后来就被消声了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10071932021, createdName=少年尼采, createdTime=Sat Oct 29 13:22:36 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2016-10-29 ellenli

    治病,预防先行

    0

  10. 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content=北京的霾为医学医院?增加了负担啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Sat Oct 29 15:41:35 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151957, encodeId=fd5115195e0b, content=治病,预防先行, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib1VDvmgcW1U7iatqib3zWp2hc0XDjkia6BWsQg86Bmjv2kgwZb11orQeIrV5czIiaOnmnrxyJiaMPrzzL6qibkLiazYX05/0, createdBy=07481682680, createdName=ellenli, createdTime=Sat Oct 29 13:38:21 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151948, encodeId=08af1519488c, content=复旦公共卫生学院做过上海 2.5颗粒有毒有害分析 后来就被消声了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10071932021, createdName=少年尼采, createdTime=Sat Oct 29 13:22:36 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2016-10-29 少年尼采

    复旦公共卫生学院做过上海 2.5颗粒有毒有害分析 后来就被消声了?

    0

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