KIDNEY INT:急性肾损伤与心肌梗死后微血管心肌损害有关!

2017-04-16 xing.T MedSci原创

因此,在血管再通的STEMI患者中,采用CMR评估的微血管损伤存在与AKI风险增加独立相关。这意味着心脏微血管病变与STEMI之后发生的肾损伤之间存在一个潜在的病理生理学联系。

急性肾损伤(AKI)是急性ST段抬高型心肌梗死(STEMI)患者进行急诊经皮冠状动脉介入治疗后一种常见的并发症。然而,在这中情况下发生AKI的病理生理较为复杂,超越了对照剂的管理。当前评估梗死特征对AKI影响的研究是缺乏的,近日,肾脏病领域权威杂志kidney international上发表了一篇研究文章,在这项研究中,研究人员旨在通过分析361例接受急诊经皮冠状动脉介入治疗的STEMI患者来明确AKI与心肌和微血管损伤之间的相关性。

在这些参与者中,有318例患者被纳入最终分析。研究人员测定了患者入院24、48和72小时后血清肌酐水平,AKI定义为增加的血清肌酐超过0.3mg/dL。在梗死后第一周进行心脏磁共振(CMR)扫描,并且通过晚期钆增强CMR来可视化微血管损伤。

16名患者发生AKI,他们的左室射血分数(45 [四分位间距范围为40-52%] vs. 54 [47-59%])显著降低,梗死的左室心肌质量较大(21 [15-35]% vs. 12[7-22]%),微血管损伤(81% vs. 46%)更频繁,相比于那些没有发生AKI的患者。有意思的是,在多变量分析中包含了所有的CMR数据,微血管损伤是AKI的独立预测因子(比值比为6.74,95%可信区间为1.49-30.43)。

因此,在血管再通的STEMI患者中,采用CMR评估的微血管损伤存在与AKI风险增加独立相关。这意味着心脏微血管病变与STEMI之后发生的肾损伤之间存在一个潜在的病理生理学联系。

原始出处:

Sebastian Johannes Reinstadler,et al. Acute kidney injury is associated with microvascular myocardial damage following myocardial infarction.kidney-international.2017. http://www.kidney-international.org/article/S0085-2538(17)30149-7/fulltext

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    2017-04-26 1ddf0692m34(暂无匿称)

    涨知识,学习了

    0

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    2017-04-19 大爰

    好文章学习了分享了!

    0

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    2017-04-18 mgqwxj
  4. 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  5. 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level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Mon Apr 17 10:47:46 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187993, encodeId=097018e993bb, content=急性肾损伤(AKI)是急性ST段抬高型心肌梗死(STEMI)患者进行急诊经皮冠状动脉介入治疗后一种常见的并发症, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Sun Apr 16 21:02:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187977, encodeId=219e18e977c2, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Apr 16 20:02:35 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187902, encodeId=fe7218e902fb, content=非常好的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 16 12:42:11 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187901, encodeId=4e1418e901c3, content=不错哦,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun Apr 16 11:51:13 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-18 gwc389
  6. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Tue Apr 18 02:14:00 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603027, encodeId=f495160302ec1, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Tue Apr 18 02:14:00 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188199, encodeId=2e11188199e6, content=学习了不少事情, beContent=null, objectType=article, channel=null, 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encodeId=219e18e977c2, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Apr 16 20:02:35 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187902, encodeId=fe7218e902fb, content=非常好的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 16 12:42:11 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187901, encodeId=4e1418e901c3, content=不错哦,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun Apr 16 11:51:13 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-17 圣艮山

    学习了不少事情

    0

  7. 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level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Mon Apr 17 10:47:46 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187993, encodeId=097018e993bb, content=急性肾损伤(AKI)是急性ST段抬高型心肌梗死(STEMI)患者进行急诊经皮冠状动脉介入治疗后一种常见的并发症, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Sun Apr 16 21:02:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187977, encodeId=219e18e977c2, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Apr 16 20:02:35 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187902, encodeId=fe7218e902fb, content=非常好的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 16 12:42:11 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187901, encodeId=4e1418e901c3, content=不错哦,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun Apr 16 11:51:13 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-16 knowheart

    急性肾损伤(AKI)是急性ST段抬高型心肌梗死(STEMI)患者进行急诊经皮冠状动脉介入治疗后一种常见的并发症

    0

  8. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Tue Apr 18 02:14:00 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603027, encodeId=f495160302ec1, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Tue Apr 18 02:14:00 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188199, encodeId=2e11188199e6, content=学习了不少事情, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Mon Apr 17 10:47:46 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187993, encodeId=097018e993bb, content=急性肾损伤(AKI)是急性ST段抬高型心肌梗死(STEMI)患者进行急诊经皮冠状动脉介入治疗后一种常见的并发症, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Sun Apr 16 21:02:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187977, encodeId=219e18e977c2, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Apr 16 20:02:35 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187902, encodeId=fe7218e902fb, content=非常好的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 16 12:42:11 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187901, encodeId=4e1418e901c3, content=不错哦,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun Apr 16 11:51:13 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-16 dhzzm

    学习了分享了

    0

  9. 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encodeId=219e18e977c2, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Apr 16 20:02:35 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187902, encodeId=fe7218e902fb, content=非常好的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 16 12:42:11 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187901, encodeId=4e1418e901c3, content=不错哦,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epr1MZHfgreGEFrpiapjCGIQGZhkpjicialc8h7VoU0AjNiaSgpaZjNuIqq1KVbmI19JwrN2sdwTdWVSw/132, createdBy=f6692009961, createdName=sy3923582, createdTime=Sun Apr 16 11:51:13 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-16 虈亣靌

    非常好的文章,学习了

    0

  10. 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encodeId=219e18e977c2, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Apr 16 20:02:35 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187902, encodeId=fe7218e902fb, content=非常好的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 16 12:42:11 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187901, encodeId=4e1418e901c3, content=不错哦,学习了, 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    2017-04-16 sy3923582

    不错哦,学习了

    0

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