JAHA:冠状动脉搭桥术后新发围手术期房颤与长期不良事件风险

2021-05-29 MedSci原创 MedSci原创

心脏手术后POAF患者不良结局的长期风险增加,主要包括死亡和心肌梗死。POAF患者卒中风险较低,且并未增加。

围手术期房颤(POAF)在心脏手术患者中很常见。心脏手术后POAF患者发生卒中和其他不良事件的长期风险是否增加,存在相互矛盾的证据。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,在这项国际研究中,研究人员对4624例既往无房颤的冠状动脉搭桥术患者进行了长达5年的前瞻性随访。POAF定义为首次手术住院期间发生的房颤,持续时间≥5分钟,且需要治疗。该研究的结局为死亡、非致死性心肌梗死或非致死性卒中的复合结局,及其单个成分。

该研究参与者的中位年龄为67岁,有778例(16.8%)患者发生POAF。伴有和不伴有POAF的患者,复合结局发生率分别为6.84人和4.10人/100名患者每年,卒中发生率分别为0.75和0.45。复合结局的调整风险比(aHRs)为1.36 (95%CI为1.16-1.59);死亡风险比为1.33(95%可信区间为1.10-1.61);心肌梗死风险比为1.58 (95%CI为1.23-2.02)、卒中风险比为1.27 (95%CI为0.81-2.00)。

不同结局的比例

在排除首次入院事件的里程碑式分析中,复合结局的aHR为1.26 (95%CI为1.03-1.54),死亡为1.28 (95%CI为1.03-1.59),心肌梗死为1.70 (95%CI为0.86-3.36),卒中为1.07 (95%CI为0.59-1.93)。出院时,分别有10.7%和1.4%的POAF患者和非POAF患者接受了口服抗凝治疗。

由此可见,心脏手术后POAF患者不良结局的长期风险增加,主要包括死亡和心肌梗死。POAF患者卒中风险较低,且并未增加

原始出处:

David Conen.et al.New‐Onset Perioperative Atrial Fibrillation After Coronary Artery Bypass Grafting and Long‐Term Risk of Adverse Events: An Analysis From the CORONARY Trial.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.020426

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    2021-05-31 zhaohui6731
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    2021-05-31 zzc2214
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    2021-05-30 心介

    房颤,临床上碰到很多哦

    0

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