Nature: 基于CRISPR的SARS-CoV-2快速诊断技术

2020-04-17 Nature自然科研 Nature自然科研

《自然-生物技术》本周发表的一篇论文CRISPR–Cas12-based detection of SARS-CoV-2 报道了一种基于CRISPR的诊断工具可以快速检测出SARS-CoV

《自然-生物技术》本周发表的一篇论文CRISPR–Cas12-based detection of SARS-CoV-2 报道了一种基于CRISPR的诊断工具可以快速检测出SARS-CoV-2。这一诊断工具大概需要45分钟就能给出结果,准确性与传统的RT-PCR检测相当。

之前的疾病大流行告诉我们,快速且易获取的检测方法对于实现有效的公共卫生响应很重要。然而,目前的SARS-CoV-2检测方法往往需要几小时甚至几天才能出结果。

一种基于CRISPR–Cas12的检测SARS-CoV-2 的测试 来源:Broughton et.al
美国加州大学的邱华彦和同事报道了一种基于CRISPR–Cas12的测试方法,可以从COVID-19患者呼吸道拭子提取的RNA中鉴定出SARS-CoV-2。这个测试名为“SARS-CoV-2的DNA内切酶靶向CRISPR反式报告系统”(DETECTR)。测试需要先取得样本RNA,然后将其逆转录到DNA中,再通过一种名为等温扩增的技术进行扩增。之后,SARS-CoV-2包膜(envelope,E)和核衣壳(nucleocapsid,N)的基因序列就可以被CRISPR–Cas12检测到,CRISPR–Cas12会切割确认病毒存在的报告分子。作者利用36名COVID-19患者和42名其他呼吸道疾病患者的临床样本测试了该系统。与美国疾病预防与控制中心使用的RT-PCR检测相比,该测试的阳性预测符合率为95%,阴性预测符合率为100%。

RT-PCR的检测一般要等几个小时,还需要使用特殊设备、进行冷热循环;与之相比,DETECTR只有两个固定的操作温度,大约45分钟后,就能像家用验孕测试一样,在可视化读出条上读取结果。

原始出处:
James P. Broughton, et al. CRISPR–Cas12-based detection of SARS-CoV-2. Nature. Published: 16 April 2020

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    2020-11-16 liye789132251
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    2020-10-22 hukaixun
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    2020-08-27 14818eb4m67暂无昵称

    学习了

    0

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    2020-04-19 yuandd
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    2020-04-19 小刀医生

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