PLoS MED：二手烟让儿童更易受肺结核侵袭

2015-06-11 MedSci MedSci原创

根据最近的全球卫生统计，肺结核是全球十大致死病因之一，并且在大多数高负担地区仅次于心血管疾病（CVD）。在最新的WHO全球肺结核报告中，据估计全球有三分之一的人口被结核杆菌感染。每年有860万人患上肺结核，有130万人最终死于这一疾病。最近烟草再次成为了肺结核的风险因素研究对象。有证据表明二手烟对肺部的免疫系统有损害。这直接导致了更容易被结核杆菌感染并进而发展成为肺结核。但是二手烟暴露和肺结核的联

根据最近的全球卫生统计，肺结核是全球十大致死病因之一，并且在大多数高负担地区仅次于心血管疾病（CVD）。在最新的WHO全球肺结核报告中，据估计全球有三分之一的人口被结核杆菌感染。每年有860万人患上肺结核，有130万人最终死于这一疾病。最近烟草再次成为了肺结核的风险因素研究对象。有证据表明二手烟对肺部的免疫系统有损害。这直接导致了更容易被结核杆菌感染并进而发展成为肺结核。但是二手烟暴露和肺结核的联系尚未完全被了解。研究人员对18项观察性研究进行了系统综述和meta分析。

研究人员在PubMed、Embase、Scopus、web of science和谷歌学术进行了系统性文献检索。主要筛选条件是对潜在的肺结核感染（LTBI）和肺结核患病的原创性研究。共有18项研究符合检索条件，这包括了30757名儿童和44432名成人非吸烟者。儿童的与二手烟暴露量相关的LTBI的相对风险与总体影响相似，有着很高的不均匀性。相对于成年人，儿童有着三倍的风险因二手烟而患肺结核。在五岁以下儿童、通过父母而暴露在二手烟下的儿童以及生活在最拥挤的居住条件下的儿童中，研究人员发现了二手烟暴露量-响应之间的正相关。这意味着暴露在二手烟下的儿童更易感染肺结核。

此次研究表明，二手烟暴露量和肺结核患病的相对风险的增高有关。当然由于研究存在较高的不均匀性，这一分析或许不能提供充足的证据来确证这一联系。但这表明国家禁烟以及保护生活在二手烟环境下的儿童有着重要的意义。

原始出处：

Patra J, Bhatia M, Suraweera W, Morris SK, Patra C, Gupta PC, et al. (2015) Exposure to Second-Hand Smoke and the Risk of Tuberculosis in Children and Adults: A Systematic Review and MetaAnalysis of 18 Observational Studies. PLoS Med 12(6): e1001835. doi:10.1371/journal.pmed.1001835

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2015-06-26 huaxipanxing

看看

117 0
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2015-06-17 summer474cn

！

122 0
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2015-06-12 huhuaidong387

#结核#

35 0
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2015-06-12 12498c24m69暂无昵称

#二手烟#

0 0
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2015-06-12 ms3994565386320060

#Med#

38 0
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2015-06-12 hcz5759

切记切记

88 0
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2015-06-11 I+am+super

肺结核现回归

109 0
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2015-06-11 medcardio

优秀研究

157 0

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