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SCIENCE：相同的突变助力肿瘤转移

2018-09-08 海北 MedSci原创

肿瘤转移突变
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转移是导致大多数癌症相关死亡的原因。虽然原发性肿瘤内的基因组异质性与复发有关，但至今为止，我们尚未全面评估未治疗的转移灶之间的异质性。

转移是导致大多数癌症相关死亡的原因。虽然原发性肿瘤内的基因组异质性与复发有关，但至今为止，我们尚未全面评估未治疗的转移灶之间的异质性。
最近，来自斯坦福大学医学院的研究人员分析了来自20名患者的76个未治疗转移灶的测序数据，并推断了乳腺癌，结肠直肠癌，子宫内膜癌，胃癌，肺癌，黑素瘤，胰腺癌和前列腺癌的癌症系统发育。研究人员发现，在个体患者中，绝大多数驱动基因突变对于所有转移是常见的。
进一步分析显示，没有被所有转移灶共享的驱动基因突变不太可能产生功能性后果。肿瘤进化和转移形成的数学模型提供了对观察到的驱动基因同质性的解释。
因此，单个活组织检查能够捕获转移中大多数功能上重要的突变，为治疗决策提供必要信息。

原始出处：
Johannes G. Reiter et al. Minimal functional driver gene heterogeneity among untreated metastases. Science, 2018; 361 (6406): 1033 DOI: 10.1126/science.aat7171

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    2018-09-21 13718711b3m

    值得借鉴与学习的临床经验，涨知识，受益匪浅，谢谢分享！

    0

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    2018-09-10 sunyl07

    #肿瘤转移#

    0

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    2018-09-10 jichang

    #SCIE#

    0

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    2018-09-09 kafei

    学习了谢谢

    0

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    2018-09-08 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦

    0

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