Neurology：氯胺酮治疗新生儿及儿童难治性癫痫持续状态

2022-09-02 Naomi MedSci原创

神经新前沿

企业/

近日，一项发表在Neurology上的研究旨在描述氯胺酮对儿童和新生儿 RSE 的影响。研究发现，氯胺酮治疗与少量不良事件相关，氯胺酮治疗后癫痫发作常常终止或改善。

关于儿童和新生儿使用麻醉剂治疗难治性癫痫持续状态(RSE)的数据很少，尽管数据有限，氯胺酮的使用仍在增加。近日，一项发表在Neurology上的研究旨在描述氯胺酮对儿童和新生儿 RSE 的影响。

方法: 回顾性单中心队列研究连续入住第四护理儿童医院重症监护病房接受氯胺酮输注治疗 RSE 的患者。

结果:

69例患者输注氯胺酮治疗 RSE。RSE 发病的中位年龄为0.7岁(IQR 0.15-7.2) ，该队列包括13名(19%)新生儿。
3名患者(4%)在服用氯胺酮12小时内发生不良事件，包括2名患者高血压和1名患者谵妄。
氯胺酮输注后，32例(46%)患者癫痫发作终止，19例(28%)患者癫痫发作减少，18例(26%)患者无变化。

氯胺酮治疗与少量不良事件相关，氯胺酮治疗后癫痫发作常常终止或改善。需要进一步的数据比较一线和随后的麻醉药物治疗小儿和新生儿 RSE。证据分类: 本研究为氯胺酮治疗儿童和新生儿 RSE 的疗效提供了第四类证据。

文献来源：Jacobwitz M, Mulvihill C, Kaufman MC, et al. Ketamine for Management of Neonatal and Pediatric Refractory Status Epilepticus [published online ahead of print, 2022 Jul 11]. Neurology. 2022;10.1212/WNL.0000000000200889. doi:10.1212/WNL.0000000000200889

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2023-05-17 yinhl1978

#Neurol#

136 0 举报
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2022-09-03 jml2009

#氯胺酮#

161 0 举报
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2022-09-03 freve

#难治性#

201 0 举报
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2022-09-02 小小医者

背后可能都是#基因突变#导致的#难治性癫痫#，治疗难度极大

252 0 举报

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