Int J Cardiol:先天性心脏病患儿感染性心内膜炎的危险因素分析!

2017-08-19 xing.T MedSci原创

由此可见,该研究表明CHD病变患者IE的风险明显有所不同。侵入性心脏手术,而不是牙科手术,与CHD儿童的IE显著相关。

感染性心内膜炎(IE)在儿童时期很少见。先天性心脏病(CHD)患者的IE的相关流行病学特征尚不清楚。

近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员纳入了1997年到2005年期间在台湾出生的并且在3岁前确诊为CHD的儿童。所有患儿随访至2010年底、诊断感染性心内膜炎或死亡。研究人员收集了伴有和不伴有IE患者的人口统计学特征、索引日期6个月前的侵入性手术、牙科手术相关的预防抗生素和住院死亡率。

研究人员对24729例CHD患儿的资料进行了回顾性分析,并确定了237例新诊断为IE的患者。在所有CHD病变患者发生IE的发病率为11.13人每10000人每年。以ASD为参考,以下CHD病变的IE风险如下:紫绀型先心病(比值比为9.58;95%可信区间为5.38-17.05),心内膜垫缺损(ECD)(8.01;2.73-23.50),左侧病变(4.36;1.90-10.01)和室间隔缺损(2.93;1.64-5.23)。接受手术操作的患者有较高的获得性IE风险,这些操作包括中心静脉导管(CVC)插入(3.17;2.36-4.27)、心导管(3.74;2.67-5.22)、开胸手术(2.47;1.61-3.77)、瓣膜手术(3.20;1.70-6.02)和分流手术(7.43 2.36-23.41)。然而,牙科手术并没有增加IE的风险,无论是否使用抗生素

由此可见,该研究表明CHD病变患者IE的风险明显有所不同。侵入性心脏手术,而不是牙科手术,与CHD儿童的IE显著相关。

原始出处:

Li-Chuan Sun, et al. Risk factors for infective endocarditis in children with congenital heart diseases - A nationwide population-based case control study.International Journal of Cardiology.2017.http://dx.doi.org/10.1016/j.ijcard.2017.08.009

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createdBy=583d24724321, createdName=charl1234575, createdTime=Mon Feb 19 01:36:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708402, encodeId=43521e0840260, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Sun Jun 03 15:36:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241535, encodeId=c9c92415353b, content=给临床预防又帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 19 17:26:52 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-09-07 1de3b290m83(暂无匿称)

    给临床预防又帮助

    0

  5. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 19 17:26:52 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-23 1e1263e3m20(暂无匿称)

    学习了多谢分享

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 19 17:26:52 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-21 往日如昨

    学习了谢谢分享

    0

  7. 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encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Mon Aug 21 03:36:00 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235420, encodeId=408b23542091, content=学习了不少事情!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Sun Aug 20 15:27:17 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235134, encodeId=c7b023513429, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 19 17:26:52 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1781799, encodeId=307d1e8179917, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu May 10 03:36:00 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655386, encodeId=8a0a1655386b2, content=<a href='/topic/show?id=7c2853311ac' target=_blank style='color:#2F92EE;'>#感染性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53311, encryptionId=7c2853311ac, topicName=感染性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon Aug 21 15:45:47 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350689, encodeId=414f135068963, content=<a href='/topic/show?id=a32d508e8c3' target=_blank style='color:#2F92EE;'>#心内膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50878, encryptionId=a32d508e8c3, topicName=心内膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Aug 21 03:36:00 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369309, encodeId=9e92136930927, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Mon Aug 21 03:36:00 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235420, encodeId=408b23542091, content=学习了不少事情!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Sun Aug 20 15:27:17 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235134, encodeId=c7b023513429, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 19 17:26:52 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-21 huirong
  9. [GetPortalCommentsPageByObjectIdResponse(id=1781799, encodeId=307d1e8179917, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu May 10 03:36:00 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655386, encodeId=8a0a1655386b2, content=<a href='/topic/show?id=7c2853311ac' target=_blank style='color:#2F92EE;'>#感染性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53311, encryptionId=7c2853311ac, topicName=感染性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 19 17:26:52 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-20 圣艮山

    学习了不少事情!

    0

  10. 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encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Mon Aug 21 03:36:00 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235420, encodeId=408b23542091, content=学习了不少事情!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Sun Aug 20 15:27:17 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235134, encodeId=c7b023513429, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 19 17:26:52 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-19 清风拂面

    谢谢分享,学习了

    0

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在疑似冠状动脉心脏病(CHD)患者中,有创性血管造影率过高。本研究旨在检验这一假设——疑似CHD患者中,心血管磁共振(CMR)指导护理在减少不必要的检查上优于英国国家卫生与临床优化研究所(NICE)的指南推荐的护理和心肌灌注显像(MPS)指导护理。 此多中心,3个平行组,随机临床试验在英国6家医院进行,纳入1202例有症状的疑似CHD的患者,CHD检测可能性为10%-90%。第一个随机组是在

JAHA:循环成纤维细胞生长因子21在2型糖尿病患者冠心病初级预防中的作用!

研究人员首次证明了血清FGF21水平是冠心病发病的一个独立预测因子,在初级预防中其可以作为鉴别2型糖尿病患者冠心病风险升高个体的有用的生物标志物。

JAMA:轮班制增加心脏病风险,医务人员尤其如此

背景民众对轮班制工作与患冠心病(CHD)风险之间的关系并不了解,且既往研究都仅对参与者进行短期随访,结果并不具备可信性。 目的该研究的目的是评估轮班工作是否增加民众患冠心病的风险。 方式该研究为前瞻性队列研究,共有189158名参与护士1期健康研究(NHS,1988-2012,N=73623)和护士2期健康研究(NHS2,1989-2013,N =115535)的健康女性参与研究,研究人员对她们进

Heart:肝细胞生长因子作为冠心病的生物标志物具有种族异质性!

在这个大型不同人群为基础的队列中,研究人员报道了HGF与亚临床CHD和CHD发生相关。研究人员证实了这些相关性中种族/族裔存在异质性,结果在非裔美国人和非西班牙裔白人中最为引人注目。该研究提供的证据表明HGF是动脉粥样硬化疾病的生物标志物,并且独立于传统的危险因素。

Hypertension:孕妇使用抗高血压药物和子代先天性心脏病有啥关系?

该研究结果支持和扩展了早期NBDPS的研究结果,即抗高血压药物使用可能与特异性CHD的风险增加有关,尽管我们不能完全排除潜在疾病特征的混杂影响。