JAHA:NT-proBNP与房颤发生风险种族差异相关

2019-03-27 不详 MedSci原创

黑种人的心血管疾病风险因素要多于白种人,但房颤的发生率却低于白种人,相反,白种人的心衰风险更低。在白人中,N末端前B型钠尿肽(NT-proBNP)水平较高,可预测房颤的发生,并在心室舒张压升高的情况下具有利尿作用,这可能为这些种族差异提供统一的解释。本研究纳入了4731名CHS临床研究中参与者(770名黑种人)和12418名ARIC临床研究的参与者(3091名黑种人),其中分别有1277名和125

黑种人的血管疾病风险因素要多于白种人,但房颤的发生率却低于白种人,相反,白种人的心衰风险更低。在白人中,N末端前B型钠尿肽(NT-proBNP)水平较高,可预测房颤的发生,并在心室舒张压升高的情况下具有利尿作用,这可能为这些种族差异提供统一的解释。

本研究纳入了4731名CHS临床研究中参与者(770名黑种人)和12418名ARIC临床研究的参与者(3091名黑种人),其中分别有1277名和1253名房颤患者。与黑种人相比,白种人基线NT-proBNP水平更高,房颤的发生风险也更高。NT-proBNP水平可以解释房颤风险的种族差异。与假设不一致的是,尽管CHS临床研究中白种人的心衰风险更低,但在ARIC临床研究中无统计学差异。

研究结果显示,房颤发生风险的种族差异可以由基线NT-proBNP水平的差异解释。

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    2019-03-29 zhaohui6731
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    2019-03-29 huiwelcome
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    2019-03-29 mjldent
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    2019-03-29 sunylz

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