J Thromb Haemost:血栓形成倾向患者骨科手术后静脉血栓栓塞高风险

2020-11-15 MedSci原创 MedSci原创

骨科手术后发现患有V因子莱顿、高VIII因子或非O血型的患者发生VTE的风险较高。识别这些患者可以使个体化的血栓预防治疗有效地降低VTE风险。

近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,这项研究旨在评估血栓形成倾向对接受任何类型的骨科手术患者的VTE风险的影响。接受骨科手术的患者存在静脉血栓栓塞(VTE)的高风险。尽管血栓形成倾向患者的VTE风险增加,但目前尚不清楚在接受骨科手术的血栓形成倾向患者中是否具有协同作用。


 
研究人员使用了基于大型人群的病例对照研究(静脉血栓形成危险因素的多环境和遗传评估[MEGA]研究)的数据。对于接受任何骨科手术的患者,计算出年龄、性别和体重指数(BMI)(ORadj)调整后的比值比(OR)和95%置信区间(CI)。


 
在4721例病例和5638例对照者中,263例和94例接受了骨科手术。在索引日期之前的一年中进行过骨科手术的患者比未进行过骨科手术的患者发生VTE的风险更高(ORadj为3.7; 95%CI为2.9-4.8)。 V莱顿因子(OR为17.5,95%CI为4.1-73.6)、非O血型(OR为11.2; 95%CI为3.4-34.0)或血浆VIII因子血浆水平升高(OR为18.6,95%CI为7.4-46.9)的患者风险进一步增加;均相对于没有这些缺陷且未接受骨科手术的患者。
 
由此可见,骨科手术后发现患有V因子莱顿、高VIII因子或非O血型的患者发生VTE的风险较高。识别这些患者可以使个体化的血栓预防治疗有效地降低VTE风险。
 
原始出处:
 
Roberto Zambelli.et al.High risk of venous thromboembolism after orthopedic surgery in patients with thrombophilia.Journal of Thrombosis and Haemostasis.2020.https://doi.org/10.1111/jth.15163

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    2021-07-13 changfy
  2. 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    2021-04-06 xue8602
  3. 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    2021-05-19 Jiwenma

    想找血栓机制类文章在这类杂志上可以找到最新研究吗

    0

  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0771857733, createdName=ms3642304794529736, createdTime=Sun Nov 15 13:52:09 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2008490, encodeId=4f97200849033, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Tue Jul 13 00:56:59 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955516, encodeId=a4f919555167c, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, 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topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Fri Mar 12 15:56:59 CST 2021, time=2021-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1698165, encodeId=922d16981657e, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sun Apr 18 19:56:59 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955088, encodeId=72e595508841, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d715474743, createdName=ms5000000708886456, createdTime=Wed Apr 07 23:04:30 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899871, encodeId=f1808998e1bc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac555424952, createdName=ms8000001754662727, createdTime=Tue Nov 17 14:55:54 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448903, encodeId=04d41448903ed, content=<a href='/topic/show?id=cd74101e9529' target=_blank style='color:#2F92EE;'>#骨科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101795, encryptionId=cd74101e9529, topicName=骨科手术)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210116/95d1b258331c4bc19e587ac44e4847bc/81f31ceb8b384fb8b2f04083b221b430.jpg, createdBy=85585453324, createdName=朱睿睿, createdTime=Tue Nov 17 03:56:59 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532527, encodeId=143e153252e7e, content=<a href='/topic/show?id=407e8909e30' target=_blank style='color:#2F92EE;'>#血栓形成倾向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89097, encryptionId=407e8909e30, topicName=血栓形成倾向)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=619012348612, createdName=lishizhe, createdTime=Tue Nov 17 03:56:59 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899310, encodeId=d693899310de, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0771857733, createdName=ms3642304794529736, createdTime=Sun Nov 15 13:52:09 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2021-04-18 fusion
  6. [GetPortalCommentsPageByObjectIdResponse(id=2008490, encodeId=4f97200849033, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Tue Jul 13 00:56:59 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955516, encodeId=a4f919555167c, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, 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authenticateStatus=null, createdAvatar=null, createdBy=9d715474743, createdName=ms5000000708886456, createdTime=Wed Apr 07 23:04:30 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899871, encodeId=f1808998e1bc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac555424952, createdName=ms8000001754662727, createdTime=Tue Nov 17 14:55:54 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448903, encodeId=04d41448903ed, content=<a href='/topic/show?id=cd74101e9529' target=_blank style='color:#2F92EE;'>#骨科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101795, encryptionId=cd74101e9529, topicName=骨科手术)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210116/95d1b258331c4bc19e587ac44e4847bc/81f31ceb8b384fb8b2f04083b221b430.jpg, createdBy=85585453324, createdName=朱睿睿, createdTime=Tue Nov 17 03:56:59 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532527, encodeId=143e153252e7e, content=<a href='/topic/show?id=407e8909e30' target=_blank style='color:#2F92EE;'>#血栓形成倾向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89097, encryptionId=407e8909e30, topicName=血栓形成倾向)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=619012348612, createdName=lishizhe, createdTime=Tue Nov 17 03:56:59 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899310, encodeId=d693899310de, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0771857733, createdName=ms3642304794529736, createdTime=Sun Nov 15 13:52:09 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2021-04-07 ms5000000708886456

    感谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2008490, encodeId=4f97200849033, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Tue Jul 13 00:56:59 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955516, encodeId=a4f919555167c, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, 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topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Fri Mar 12 15:56:59 CST 2021, time=2021-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1698165, encodeId=922d16981657e, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sun Apr 18 19:56:59 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955088, encodeId=72e595508841, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d715474743, createdName=ms5000000708886456, createdTime=Wed Apr 07 23:04:30 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899871, encodeId=f1808998e1bc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac555424952, createdName=ms8000001754662727, createdTime=Tue Nov 17 14:55:54 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448903, encodeId=04d41448903ed, content=<a href='/topic/show?id=cd74101e9529' target=_blank style='color:#2F92EE;'>#骨科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101795, encryptionId=cd74101e9529, topicName=骨科手术)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210116/95d1b258331c4bc19e587ac44e4847bc/81f31ceb8b384fb8b2f04083b221b430.jpg, createdBy=85585453324, createdName=朱睿睿, createdTime=Tue Nov 17 03:56:59 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532527, encodeId=143e153252e7e, content=<a href='/topic/show?id=407e8909e30' target=_blank style='color:#2F92EE;'>#血栓形成倾向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89097, encryptionId=407e8909e30, topicName=血栓形成倾向)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=619012348612, createdName=lishizhe, createdTime=Tue Nov 17 03:56:59 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899310, encodeId=d693899310de, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0771857733, createdName=ms3642304794529736, createdTime=Sun Nov 15 13:52:09 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2020-11-17 ms8000001754662727

    学习了

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0771857733, createdName=ms3642304794529736, createdTime=Sun Nov 15 13:52:09 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=2008490, encodeId=4f97200849033, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Tue Jul 13 00:56:59 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955516, encodeId=a4f919555167c, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, 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  10. 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    2020-11-15 ms3642304794529736

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