JACC:死亡风险降低68%!2型糖尿病患者坚持4种健康生活方式,可大幅度减少心脑血管并发症的发生和死亡风险

2018-08-08 奇点糕 奇点网

时代在发展,大家的生活方式也在发生改变,我们日常饮食摄入的热量越来越高,肥胖人数和2型糖尿病的发病率也在逐年攀升,根据国际糖尿病联盟的数据显示,2017年全球20-79岁的糖尿病患者达到了4.25亿,其中,2型糖尿病约占全球糖尿病总数的90%。而我国的形势也很严峻,平均每9个成年人,就有一人患2型糖尿病。

时代在发展,大家的生活方式也在发生改变,我们日常饮食摄入的热量越来越高,肥胖人数和2型糖尿病的发病率也在逐年攀升,根据国际糖尿病联盟的数据显示,2017年全球20-79岁的糖尿病患者达到了4.25亿,其中,2型糖尿病约占全球糖尿病总数的90%。而我国的形势也很严峻,平均每9个成年人,就有一人患2型糖尿病。

在这样庞大的人群基数下,今天,奇点糕就和大家说一说,在被确诊了2型糖尿病之后,除了乖乖吃药,我们还应该做些什么来保证自己的生活质量。



上图为中华医学会糖尿病学分会绘制的2型糖尿病高血糖治疗简易路径。看到左边那条贯穿全程的“生活方式干预”了吗?它就是我们今天的主角。

生活方式究竟会对2型糖尿病患者的血管疾病发生及死亡风险产生多大的影响?一项由哈佛大学公共卫生学院主导、中国科学院上海生命科学研究院参与的,包含了11527名患者随访13.3年的队列研究显示,确诊2型糖尿病后保持健康的生活方式,血管疾病发生风险降低52%,死亡风险降低68%!相关文章发表在了《美国心脏病学会杂志》上。


通讯作者 Qi Sun博士

被确诊了2型糖尿病,可能还有朋友不往心里去,对控制血糖也不上心,血糖水平忽高忽低,长期的高血糖会损伤多个器官或组织,导致并发症,比如糖尿病肾病、糖尿病眼部并发症、糖尿病性心、脑血管病等等。对于患者来说,2型糖尿病本身可能并不致命,这些并发症才是最可怕的!调查显示,在我国,73.2%的糖尿病患者伴有一种或多种慢性并发症!

这其中,心脑血管的并发症尤其值得注意,它影响的人数是最多的,占到全部患者的一半以上。心脑血管疾病在健康人中是第一大杀手,在糖尿病患者中更加猖狂,糖尿病患者的发病风险与非糖尿病人群相比要高4倍,在门诊就诊的2型糖尿病患者中,血糖、血压和血脂控制综合达标率仅为5.6%。

对于慢性疾病来说,再有效的药物也得配合良好的生活方式,比如健康饮食,适当运动,适量饮酒,不吸烟等等。虽然是老生常谈,但是,好的生活方式到底能减少多少患病和死亡风险,这种量化的评估对于患者来说非常重要。

几个月之前,奇点糕刚跟大家科普了,健康的人保持一个良好的生活方式,可以大幅度降低心血管疾病和癌症的风险,至少能够延寿12年。巧的是,这篇文章中提到的良好的生活方式与我们这次的新研究是非常相似的,对于健康人都有如此好的效果,那想必,糖尿病患者的受益应该也不会小。

研究包括了护士健康研究(Nurses’ Health Study)的121,700名30-55岁的美国女护士,和健康随访研究(Health Professionals Follow-Up Study)的51529名40-75岁之间的美国男性。通过调查问卷, 每2到4年更新一次关于饮食和生活方式因素、病史和疾病状况的详细信息。排除在2型糖尿病确诊前就患有心血管疾病或者癌症及缺少详细信息的,最终共有8970名女性和2557名男性2型糖尿病患者列入了分析。

怎么样才是研究人员所认为的健康生活方式呢?健康饮食,不吸烟,中度或高强度运动时间每周达到150分钟以上,以及适度饮酒(女性每天5-15g,男性每天5-30g)。

志愿者每达成一项健康生活方式,就可以得到1分,最高为4分,最低为0分。考虑到2型糖尿病患者大部分在体重方面都会超标,所以,BMI值并未被考虑。

事实证明,被判定为生活方式健康、拿到3分及以上的人真的不多,仅有女性志愿者中的12.9%和男性志愿者中的27.4%。而一只脚勉强踏进了健康生活大门的,得到了2分的志愿者的人数倒是还算可观,分别占了男女总人数的34.6%和37.8%。

健康评分在3分及以上的人与0分相比,心血管疾病发生风险降低52%,冠心病发生风险降低47%,脑卒中发生风险降低67%!

如果仅仅是发病风险的降低,或许健康的生活方式还不足以被认为是和死神抗争的筹码。我们再来看一下相关的死亡率。坚持3分及以上的健康生活方式,心血管疾病死亡风险降低足足降低了68%!

记得高考时老师是怎么说的吗?“1分就是成千上万人呐”!用在这里也还是挺贴切的,因为对于2型糖尿病患者来说,生活方式评分多拿1分,就意味着更低的发病风险,更低的死亡风险,这是实打实的生存机会啊!


不同生活方式评分下,患者心血管疾病发生的风险(左)和心血管疾病死亡的风险(右),可以看到明显的逐渐下降

研究还着重对比了确诊2型糖尿病前后生活方式发生变化和疾病发生风险及死亡风险的关系。

以确诊前后生活方式保持不变的志愿者为参照,若是被确诊之后就放飞自我自暴自弃,生活方式更加差了的话,那并发症肯定不会放过他,各种疾病发生风险通通上升,其中心血管疾病死亡风险足足上升了61%!

而确诊之后开始“痛改前非”的当然就会有所收获,并发症的发生风险和死亡率都大幅度下降,平均每多拿1分,心血管疾病发生风险就可以降低14%,冠心病发生风险降低12%,脑卒中发生风险降低21%,心血管疾病死亡风险降低27%!

而患者需要做的只是每天抽出20分钟以上做些运动,增加健康食物的摄入,多吃些谷物和蔬菜,放下手中的冰阔落,或者扔掉口袋里的烟盒和打火机。

动感单车普拉提,不达目的不放弃!

其实,保持健康生活方式减少2型糖尿病的并发症,也是老生常谈了。但是健康的生活方式需要多健康?减少风险又能减少多少?作者表示,这是第一篇将二者量化、准确联系起来的文章。并且,较大的样本量和长期随访的高随访率,都是这个研究的优点。

同时,作者也指出,在长时间的随访中,医学在快速地进步,患者使用的药物可能在变化,药物对于血糖血脂等其他危险因素的控制也可能越来越好,所以,可能会对生活方式与疾病风险之间的分析造成一些干扰。但是尽管如此,保持好的生活方式对2型糖尿病患者心脑血管并发症的有益影响是不会被否定的,除了坚持服药之外,大家还是要努力改掉坏习惯,对自己的身体负责任~

原始出处:Gang L, Li Y, Yang H, et al. Influence of Lifestyle on IncidentCardiovascular Disease and Mortality in Patients With DiabetesMellitus[J]. J Am Coll of Cardiol, 2018, 71(25):2867.

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    2018-08-17 hbwxf
  3. 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target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Fri Aug 10 06:52:00 CST 2018, time=2018-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1371967, encodeId=9ea813e196763, content=<a href='/topic/show?id=ec702e877fb' target=_blank style='color:#2F92EE;'>#健康生活方式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27877, encryptionId=ec702e877fb, topicName=健康生活方式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Fri Aug 10 06:52:00 CST 2018, time=2018-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383467, encodeId=11cd138346e77, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 10 06:52:00 CST 2018, time=2018-08-10, status=1, ipAttribution=)]
    2019-03-12 丁鹏鹏
  4. 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target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Fri Aug 10 06:52:00 CST 2018, time=2018-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1371967, encodeId=9ea813e196763, content=<a href='/topic/show?id=ec702e877fb' target=_blank style='color:#2F92EE;'>#健康生活方式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27877, encryptionId=ec702e877fb, topicName=健康生活方式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Fri Aug 10 06:52:00 CST 2018, time=2018-08-10, status=1, ipAttribution=), 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    2018-08-27 jyzxjiangqin

    2型糖尿病坚持健康生活方式。

    0

  5. 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target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Fri Aug 10 06:52:00 CST 2018, time=2018-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1371967, encodeId=9ea813e196763, content=<a href='/topic/show?id=ec702e877fb' target=_blank style='color:#2F92EE;'>#健康生活方式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27877, encryptionId=ec702e877fb, topicName=健康生活方式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Fri Aug 10 06:52:00 CST 2018, time=2018-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383467, encodeId=11cd138346e77, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 10 06:52:00 CST 2018, time=2018-08-10, status=1, ipAttribution=)]
    2018-08-22 向日葵开过的旧夏天

    这样的研究真的很不错

    0

  6. 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