Lancet Gastroenterol Hepatol:过去30年全球结直肠癌的发病率和死亡率变化

2022-04-08 Nebula MedSci原创

在全球范围内,从1990年到2019年,结直肠癌病例增加了一倍以上

结直肠癌是全球第三大癌症死亡原因。鉴于最近全球结直肠癌发病率呈上升趋势,有关结直肠癌负担的最新信息可以指导筛查、早期发现和治疗策略,并有助于有效分配资源。本研究调查了过去30年全球204个国家和地区的全球、区域和国家结直肠癌负担的时间模式及其风险因素。

作为《2019年全球疾病、伤害和风险因素负担研究》(GBD) 的一部分,研究人员根据1990-2019年期间的年龄、性别和地理位置对结直肠癌的发病率、死亡率和残疾调整生命年 (DALYs) 进行了估算。采用死亡原因集合模型生成死亡率估计值。此外,研究人员还计算了可归因于已知与结直肠癌有因果关系的风险因素的 DALY。


1990年到2019年,全球结直肠癌负担的变化

在全球范围内,从1990年到2019年,结直肠癌病例增加了一倍以上,从842098例增加到了2.1700万例,死亡病例从518126增加到了1.09万例。从1990年到2019年,全球年龄标准化发病率从22.2例/10万增加到了26.7例/10万,而年龄标准化死亡率从14.3/10万下降到了13.7例/10万,年龄标准化的DALY率从308.5/10万下降到了295.5/10万。

2019年,全球结直肠癌的年龄标准化发病率和死亡率

台湾省(62.0/10万)、摩纳哥(60.7/10万)和安道尔(56.6/10万)的年龄标准化发病率最高,而格陵兰(31.4/10万)、文莱(30.3/10万)和匈牙利(28.6/10万)的年龄标准化死亡率最高。从1990年到2019年,年轻人群(<50岁)的发病率显著上升,特别是在高社会人口指数国家。

在全球范围内,低牛奶饮食(15.6%)、吸烟(13.3%)、低钙饮食(12.9%)和饮酒(9.9%)是结直肠癌DALY的主要风险因素。

综上,50岁以下人群结直肠癌发病率的增加需要研究人员、临床医生和政策制定者保持警惕,或许重新制定筛查指南亚洲和非洲的低-中等社会人口指数国家快速增长的结直肠癌负担要求这些地区加强预防、提高认知、实施更具成本效益的筛查和治疗方法。

原始出处:

GBD 2019 Colorectal Cancer Collaborators. Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Gastroenterology & Hepatology. April 07, 2022. https://doi.org/10.1016/S2468-1253(22)00044-9

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    2023-02-12 许安
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1713050, encodeId=524b1e1305055, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Feb 19 18:44:39 CST 2023, time=2023-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073545, encodeId=b79420e3545de, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Feb 12 21:44:39 CST 2023, time=2023-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065523, encodeId=ac08206552333, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sat Jun 11 02:44:39 CST 2022, time=2022-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823815, encodeId=dfd2182381527, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Mar 03 09:44:39 CST 2023, time=2023-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427595, encodeId=8fe6142e5954b, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Sun Apr 10 14:44:39 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453691, encodeId=1b9914536918a, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Apr 10 14:44:39 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1831530, encodeId=880d1831530ff, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Jan 13 00:44:39 CST 2023, time=2023-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1243968, encodeId=a12d1243968cb, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Sat Apr 09 02:44:39 CST 2022, time=2022-04-09, status=1, ipAttribution=)]
    2022-04-10 gwc384
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    2023-01-13 howi
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    2022-04-09 younei

    lancet上果然牛,感谢梅斯更新及时

    0

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