Annals of Internal Medicine:COVID-19的潜伏期为5.1天

2020-03-11 王昭月 生物探索

近日,通过对新冠病毒SARS-CoV-2感染的公开数据进行分析,约翰•霍普金斯大学彭博公共卫生学院的研究者发现,新冠肺炎COVID-19潜伏期的中位数为5.1天。该研究结果发表在期刊《Ann

近日,通过对新冠病毒SARS-CoV-2感染的公开数据进行分析,约翰•霍普金斯大学彭博公共卫生学院的研究者发现,新冠肺炎COVID-19潜伏期的中位数为5.1天。该研究结果发表在期刊《Annals of Internal Medicine》上。

研究者收集了2020年2月24日之前在湖北省以外发现的181例确诊SARS-CoV-2感染的病例数据,其中男性患者占60%。这些病例数据有73例来自中国25个省,108例来自中国以外的国家和地区,大多数病例(n = 161)都有近期去武汉旅行或居住的历史,其他人有与湖北旅客或已知感染者接触的证据,分析发现,病例从在社区中症状发作到住院的时间范围是0.2到29.9天,中位时间为1.2天。


181例确诊病例的SARS-CoV-2暴露(蓝色),症状发作(红色)和病例检测(绿色)时间

通过用对数正态模型来拟合所有病例,研究者推测COVID-19的中位潜伏期为5.1天(CI为4.5至5.8天),少于2.5%的感染者会在暴露的2.2天内(CI为1.8至2.9天)出现症状,而97.5%的感染者会在11.5天内(CI为8.2至15.6天)出现症状。


对数正态模型估计COVID-19潜伏期的累积分布函数

“根据我们对公开数据的分析,目前建议对主动监视或隔离进行14天的建议尽管会漏掉一些病例,但总归是合理的。”该研究的资深作者Justin Lessler说,医学判断结合本研究的估计,可以帮助公共卫生官员制定合理的、可信的COVID-19控制政策。

原始出处:
Stephen A. Lauer, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Annals of Internal Medicine. 10 MARCH 2020

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    2020-05-11 kalseyzl
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    2021-01-21 般若傻瓜
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    2020-07-27 jeanqiuqiu
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