ACR 2021 :白塞病的妊娠结局的荟萃分析

2021-11-16 MedSci原创 MedSci原创

密切监测白塞病患者怀孕期间的妊娠并发症和白塞病的症状,对妊娠结局非常重要!

白塞氏病是一种全身炎症性疾病,通常表现为急性炎症、口腔和生殖器溃疡、葡萄膜炎和皮肤损伤的发作。它最常见于生命的第二个和第三个十年,因此经常涉及育龄期的女性。我们工作的目的是通过系统评价和荟萃分析评估胎儿和母体并发症的患病率,以确定白塞病病对妊娠的影响。

方法:我们使用 Medline、Web of Science 和 Cochrane 图书馆对文献进行了系统回顾,这些研究从开始到 2021 年 3 月 26 日。如果研究报告了诊断为白塞病的妊娠患者队列中并发症的频率,则纳入研究。研究由两名独立审查员选择,并使用 REVMAN5.4 进行统计。

结果:共确定了 6638 项研究,其中 16 项被纳入。在妊娠期白塞氏病患者中,剖宫产率为 23%(CI 10-36%,图 1),早产率为 11%(CI 8-15%,图 2),流产率为 11%(CI 8 -14%)、先兆子痫 4% (CI 3-6%)、宫内死亡 4% (CI 2-7%)、新发高血压 6% (2-10%) 和 27% 的女性报告相关症状恶化妊娠期间的白塞氏病(CI 20-34,图 3)。

结论:大约四分之一的患者在怀孕期间经历了与 Behcet 病相关的症状恶化,十分之一的患者早产,近四分之一的患者剖腹产分娩。这些结果表明在怀孕期间密切监测白塞病患者的重要性,不仅是妊娠并发症还有白塞病症状的转归。

 

原文:Rooney L, Gorman A, Turk M, Moore L, O'Brien C, Bierbrier J, Clohessy A, Molloy E, O Neill L, Mc Auliffe F, Veale D. Behcet’s Disease: A Meta-analysis of Pregnancy Outcomes [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 10). https://acrabstracts.org/abstract/behcets-disease-a-meta-analysis-of-pregnancy-outcomes/. Accessed November 15, 2021.

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    2022-05-16 venlin
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    2021-12-02 121b12cfm24(暂无昵称)

    学习了。

    0

  5. 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  6. 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    2021-11-27 D-House

    学习了

    0

  7. 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  8. 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    2021-11-18 10518094zz
  9. 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    2021-11-17 ms4000001271387900

    学习了

    0

  10. 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    2021-11-17 易水河

    学习学习

    0

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母亲摄入AGEs水平与子代哮喘和过敏结局无关。妊娠期间暴露于AGEs对儿童发育的影响可能与产后暴露不同。

Arthritis&Rheumatology: 银屑病关节炎女性的妊娠结局与是否抗风湿治疗及其时机的关系

评估银屑病关节炎(PsA)妊娠前和妊娠期间进行抗风湿治疗(作为疾病严重程度的近似估计)与非PsA妊娠相比的妊娠结局,尤其是与抗风湿药治疗的时间和类型之间的关系。

JCEM:妊娠体重增加对妊娠期葡萄糖和胰岛素生理的影响

妊娠期间的妊娠糖尿病(GDM)对母亲和婴儿的短期和长期影响都是负面的。患有妊娠糖尿病(GDM)的妇女在妊娠期间发病的风险更高(包括妊娠高血压/子痫前期和复杂分娩(包括剖腹产)的风险)

类风湿关节炎患者妊娠期的药物使用

类风湿关节炎患者在妊娠期需要继续治疗,在选择药物时不仅要考虑到疾病的严重程度,还要考虑到药物的胎儿毒性反应。

AJOG:妊娠葡萄糖耐受不良的生理亚型与不良妊娠结局的风险。

妊娠期糖耐量减低(妊娠期糖尿病筛查试验异常)的妇女即使没有妊娠期糖尿病,也有不良妊娠结局的风险。