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MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma

期刊: BLOOD, 2020; 136 (22)

Multiple myeloma (MM) remains largely incurable despite significant advances in biotherapy and chemotherapy. The development of drug resistance is a m......

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

期刊: BLOOD, 2020; 135 (1)

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 diagnosis-relapse-germline trios......

Efficacy and safety of CAR19/22 T-cell cocktail therapy in patients with refractory/relapsed B-cell malignancies

期刊: BLOOD, 2020; 135 (1)

Antigen-escape relapse has emerged as a major challenge for long-term disease control after CD19-directed therapies, to which dual-targeting of CD19 a......

Coactivation of NF-kappa B and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion

期刊: BLOOD, 2020; 135 (2)

NF-kappa B and Notch signaling can be simultaneously activated in a variety of B-cell lymphomas. Patients with B-cell lymphoma occasionally develop cl......

Wdr26 regulates nuclear condensation in developing erythroblasts

期刊: BLOOD, 2020; 135 (3)

Mammalian red blood cells lack nuclei. The molecular mechanisms underlying erythroblast nuclear condensation and enucleation, however, remain poorly u......

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

期刊: BLOOD, 2020; 135 (3)

Protein acetylation is an important contributor to cancer initiation. Histone deacetylase 6 (HDAC6) controls JAK2 translation and protein stability an......

Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment

期刊: BLOOD, 2020; 135 (7)

Immune thrombocytopenia (ITP) is the most common acquired thrombocytopenia after chemotherapy-induced thrombocytopenia. Existing guidelines describe t......

Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia

期刊: BLOOD, 2020; 135 (10)

Chimeric antigen receptor (CAR) T cells have radically improved the treatment of B cell-derived malignancies by targeting CD19. The success has not ye......

Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis

期刊: BLOOD, 2020; 135 (11)

Mutations in the epigenetic regulators DNMT3A and IDH1/2 co-occur in patients with acute myeloid leukemia and lymphoma. In this study, these 2 epigene......

Nivolumab treatment of relapsed/refractory Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults

期刊: BLOOD, 2020; 135 (11)

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening hyperinflammatory syndrome triggered by EBV inf......

Myc-Miz1 signaling promotes self-renewal of leukemia stem cells by repressing Cebp alpha and Cebp delta

期刊: BLOOD, 2020; 135 (14)

c-Myc (Myc hereafter) is found to be deregulated and/or amplified in most acute myeloid leukemias (AMLs). Almost all AML cells are dependent upon Myc ......

The role of type 1 interferons in coagulation induced by gram-negative bacteria

期刊: BLOOD, 2020; 135 (14)

Bacterial infection not only stimulates innate immune responses but also activates coagulation cascades. Overactivation of the coagulation system in b......

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