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Clinica Chimica Acta：晚期卵巢癌细胞外小泡表面的金属蛋白酶与腹水体积和腹膜肿瘤指数的关系

2019-09-13 gladiator MedSci原创

晚期卵巢癌细胞外小泡
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既往研究表明，金属蛋白酶及其细胞外基质金属蛋白酶诱导剂(EMMPRIN)在调控生长因子受体和粘附分子的信号传递、细胞活力和细胞外基质降解等方面发挥着重要作用。本研究的目的是探讨晚期卵巢癌患者(OCPs)小细胞外囊泡(sEVs)金属蛋白酶(ADAM10、ADAM17、MMP2、MMP9、EMMPRIN)、腹水容积与腹膜肿瘤指数(EMMPRIN)水平的关系。

既往研究表明，金属蛋白酶及其细胞外基质金属蛋白酶诱导剂(EMMPRIN)在调控生长因子受体和粘附分子的信号传递、细胞活力和细胞外基质降解等方面发挥着重要作用。本研究的目的是探讨晚期卵巢癌患者(OCPs)小细胞外囊泡(sEVs)金属蛋白酶(ADAM10、ADAM17、MMP2、MMP9、EMMPRIN)、腹水容积与腹膜肿瘤指数(EMMPRIN)水平的关系。

使用流式细胞术评估交界性卵巢肿瘤患者（BOTP）（n = 20,36.5±2.5岁）和先前未治疗的晚期OCP（n = 35,56.5±2.5）的sEV表面的金属蛋白酶亚群。从BOTP和OCP的血浆中分离的CD9阳性sEV的金属蛋白酶亚群看起来非常相似。然而，在BOTP和OCP之间发现ADAM-金属蛋白酶在腹水sEV中的表达的显著差异。 OCP中sEVs金属蛋白酶的水平显著依赖于腹水体积。此外，还发现血浆sEV中ADAM10 + / ADAM17-亚群水平与腹膜癌症病变指数之间存在统计学显著性关系（R = 0.66，p <.05）。循环sEV中的金属蛋白酶和EMMPRIN水平以及个体亚群的评估可能是OCP管理的较为理想的方法。

原始出处：

Natalia V. Yunusova，Marina R. Patysheva，Metalloproteinases at the surface of small extrcellular vesicles in advanced ovarian cancer: Relationships with ascites volume and peritoneal canceromatosis index

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    2020-06-23 qblt

    #卵巢癌细胞#

    0

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    2019-10-23 ms6897892027066920

    #金属蛋白酶#

    0

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    2020-06-11 canlab

    #蛋白酶#

    0

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    2019-11-22 windight

    #CTA#

    0

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    2019-09-15 yxch36

    #癌细胞#

    0

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    2019-09-15 siiner

    #晚期卵巢癌#

    0

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    2019-09-15 xuyong530

    #腹膜#

    0

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