期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (4)
Viral and parasitic pathogens rely critically on cysteine proteases for host invasion, replication, and infectivity. Their inhibition by synthetic inh......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (7)
Controlling the global COVID-19 pandemic depends, among other measures, on developing preventive vaccines at an unprecedented pace. Vaccines approved ......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (6)
Allosteric ligands provide new opportunities to modulate G protein-coupled receptor (GPCR) function and present therapeutic benefits over orthosteric ......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (6)
O-GlcNAcylation is an O-linked beta-N-acetyl-glucosamine (O-GlcNAc)-monosaccharide modification of serine or threonine in proteins that plays a vital ......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (7)
By catalyzing a 3-3 cross-link in peptidoglycan, L,D-transpeptidases (Ldts) can cause resistance to beta-lactams in some pathogens in vitro. However, ......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (6)
C-Glycosylation in the biosynthesis of bioactive natural products is quite unique, which has not been studied well. Medermycin, as an antitumor agent ......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (6)
Imaging RNA-protein interaction in the cellular space with single molecule sensitivity is attractive for studying gene expression and regulation, but ......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (4)
While Cetuximab can be used to treat KRAS wild-type colon cancer cells by targeting EGFR and inhibiting the activation of downstream signaling pathway......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (5)
Interferon-induced transmembrane proteins (IFITMs) are S-palmitoylated proteins in vertebrates that restrict a diverse range of viruses. S-palmitoylat......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (4)
Recent advances in genome engineering have expanded our capabilities to study proteins in their natural states. In particular, the ease and scalabilit......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (4)
Construction of nitrogen-nitrogen bonds involves sophisticated biosynthetic mechanisms to overcome the difficulties inherent to the nucleophilic nitro......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (5)
Although numerous in vitro studies have shown that osmolytes are capable of stabilizing proteins, their effect on protein folding in vivo has been les......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (5)
A challenge for sensors targeting specific enzymes of interest in their native environment for direct imaging is that they rationally exploit a highly......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (3)
We report a general approach to engineering multivalent D-proteins with antibody-like activities in vivo. Mirror-image phage display and structure-gui......
期刊： ACS CHEMICAL BIOLOGY, 2021; 16 (3)
The outbreak of novel coronavirus SARS-CoV-2 has caused a worldwide threat to public health. COVID-19 patients with SARS-CoV-2 infection can develop c......
